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Induction of apoptosis by directing oncogenic Bcr-Abl into the nucleus

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Figure

Figure 1: RNTS directs Bcr-Abl from cytoplasm into the nucleus. (A) Schematic illustration of recombinant proteins F3NF, H2FA and H2FATM
Figure 2: RNTS binds Bcr-Abl directly. (A) F3NF, H2FA and H2FATM are expressed in E.coli and purified with Ni+-NTA
Figure 3: RNTS induces apoptosis and inhibits proliferation of CML cells. K562, K562/G01 and 32D-p210 cells were, respectively, treated with Ad5, RNTSTM, RNTS or RNTS in combination with LMB
Figure 4: RNTS activates p73 and its downstream target molecules. K562, K562/G01 and 32D-p210 cells were, respectively, treated with Ad5, RNTSTM, RNTS or RNTS in combination with LMB
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