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Iguratimod, a Disease Modifying Anti Rheumatic Drug, Inhibits Osteoclastogenesis and Bone Resorption through Suppression of the Nuclear Factor of Activated T Cells Signaling Pathway

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Figure

Figure 1. Effect of IGU on bone destruction in adjuvant-induced arthritis (AIA) rats. Arthritis was induced by intradermal injection of killed M
Figure 2. Histological analysis of vehicle- or IGU-treated AIA rats on day 21. ((a), (b)) TRAP hind paws
Figure 3. centage of control; (d) Pictures of bone resorption of cells (pit formation) cultured for 9 days; (e) Effects of IGU on osteoclastogenesis in vitro
Figure 5. stream of NFATc1, Tnfrsf11a; the negative regulator of NFATc1, Mafb; the negative regulator of MafB, Prdm1; NFATc1-regulated osteoclast functional gene, Ctsk, and NFATc1-regulated genes required for cell-cell fusion, Dcstamp, Ocstamp and Atp6v0d2

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