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Interferon-stimulated gene 15 induces cancer cell death by suppressing the NF-κB signaling pathway

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Figure

Figure 1: ISG15 and USP18 are induced by clioquinol (CLQ). (A) Jurkat, K562 and RPMI-8226 cells were treated with CLQ at indicated concentrations for 24 hrs followed by total RNA preparation
Figure 2: ISG15 suppresses cancer cell proliferation. (A) K562, OCI-AML2 and OPM2 cells were infected with lentiviral ISG15 for 96 hrs, followed by immunoblotting assay to evaluate ISG15 expression
Figure 3: Ectopic ISG15 and USP18 induces cancer cell apoptosis. (A) Blood cancer cells were stably infected with lentiviral ISG15 or mock lentivirus
Figure 5: ISG15 inhibits the NF-κB signaling transduction. (A) K562 cells were infected with lentiviral ISG15 for 96 hrs followed by immunoblotting assay against indicated proteins using specific antibodies

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