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FGFR1 function at the earliest stages of mouse limb development plays an indispensable role in subsequent autopod morphogenesis

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Academic year: 2020

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Figure

Fig. 1. Activity of Fgfr1Ap-2Cre revealed using Rosa-26 reporter mice. Ages ofembryos are as indicated
Fig. 4B) and then in the entire limb at later stages (Fig. 4G).In the forelimb, although Cre activity is detected at the time oflimb initiation, it starts posteriorly and then gradually extends
Fig. 4. Activity of Hoxb6-Cre revealed by analysis ofRosa-26 reporter mice. Ages of embryos are as indicated;the number of pairs of somites are: 8 (A), 25 (B,D,F), 20(C) and 22 (E) pairs of somites
Fig. 6. Abnormal autopod formation and patterning inAlcian Blue stained P1 (A) and P10 (B) hindlimbs.(C,D) Higher magnification of the fifth digit of a mutant(C), and a wild type (D)
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