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Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women

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Academic year: 2020

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Fig. 1 Estrogen influences immunoglobulin G (IgG) sialylation. Mice were ovariectomized (OVX) at 3 months of age, followed by insertion of slow-releasesialic acids and galactose on IgG-Fc of OVA-specific (OVA-spec) and OVA-depleted (OVA-dep) IgG2 measured
Fig. 2 Effects of estrogen on Fcγ receptor expression. Ovariectomized (OVX) mice at 3 months of age followed by insertion of slow-release treatmentpellets with placebo (Pla) or estrogen (E2; 0.83 μg/day)
Fig. 3 Estrogen affects expression of the sialylation enzyme in plasmablasts. Mice were ovariectomized (OVX) at 3 months of age, followed by insertion ofanalysis of variance (ANOVA) followed by the Bonferroni multiple-comparisons test.expression of OVA-spe
Fig. 4 Estrogen increases immunoglobulin G (IgG) glycosylation in postmenopausal patients with rheumatoid arthritis (RA)

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