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Sodium Chloride Aggravates Arthritis via Th17 Polarization

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Figure

Fig. 1. NaCl induces Th17 differentiation in vitro. (A) A schematic diagram isolated from the spleens of DBA/1J mice were cultured under Th17-po-larizing conditions in the absence or presence of NaCl at different con-centrations (10, 20, 40, and 80 mM) for
Fig. 2. High-salt diet aggravates inflammatory arthritis in CIA mice. (A) Time schedule for salt ingestion in CIA mice
Fig. 3. NaCl-rich condition primes Th17 polarization in mice with CIA. (A) Flow cytometry analysis of naïve CD4of three independent experiments and are expressed as meanmice (CIA) and high-salt-fed CIA mice (CIA+NaCl)
Fig. 4. Salt intake increases IL-17 expression in the synovium and gut of CIA mice. (A-C) Expression of IL-17A in the joint synovium, small intestine, and large intestine in WT mice and CIA mice fed a normal diet (CIA) or a high-salt diet (CIA+NaCl)
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