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Mechanism and evolution of cytosolic Hedgehog signal transduction

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Figure

Table 1. Core components of the Drosophila, zebrafish and mouse Hedgehog (Hh) pathway
Fig. 1. Schematic of Hh production and reception. (characterized). Activated Ci/Gli translocates to the nucleus to activate Hh target genes
Fig. 2. Smo and Ptch trafficking
Fig. 3. Smo conformational changes, trafficking and pathway activation. Smo exists as a constitutive dimer and conformational changespermits trafficking to the primary cilium, but does not activate the pathway
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