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Developing a contrast agent for the in vivo detection of apoptosis

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Academic year: 2020

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Figure

Figure 1. Schematic representation of the two main apoptotic pathways. In the extrinsic pathway binding of an extracellular death ligand to its respective death receptor leads to the formation of the DISC complex and activation of caspase-8
Figure 2. Time progression of the major morphological and biochemical events in apoptosis
Figure 3. Schematic representation of our contrast agent. Our contrast agent consists of a dual magnetic resonance imaging/fluorescent probe coupled to a cell penetrating
Figure 4. N2A cells do not display apoptotic nuclear morphology or caspase-3 activation in response to pro-apoptotic drugs
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