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Internal radiation dosimetry of a 152Tb-labeled antibody in tumor-bearing mice

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Academic year: 2020

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Figure

Fig. 1 NEMA-NU4 phantom filled with a uniform activity of 152Tb, used to derive the count/activity calibration factor
Fig. 2 Example of manual CT-based segmentation of most relevant thoracic (heart, lungs) and abdominal organs (liver, kidneys, and intestines),along with a subcutaneous tumor on the right flank
Fig. 3 MicroPET longitudinal imaging of 152Tb-CHX-DTPA-scFv78-Fc targeting TEM-1 in a mouse bearing a subcutaneous RD-ES tumor
Fig. 4 Biological organ kinetic of the radiolabeled antibody corrected for radioisotope physical decay
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