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Hyperinsulinemia promotes aberrant histone acetylation in triple-negative breast cancer

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Figure

Fig. 1 Hyperinsulinemia in MKR mice and in vitro promotes an increase in histone acetylation
Figure S2A–F), we observed global increases in H3K9ac levels on peaks in 3 h and 6 h insulin-treated cells (Addi-tional file 1: Figure S2A–F).
Fig. 3 Insulin induces H3K9 acetylation on promoter regions. a Western blot analysis for H3K9ac in chromatin fraction or b nuclear soluble fraction (right panel) extracted from insulin-treated cells
Fig. 5 Transcription factors NRF1 is involved in insulin-mediated gene expression changes and chromatin remodeling
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