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Assessment of glutamatergic synaptic transmission and plasticity in brain slices: relevance to bioelectronic approaches

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Figure

Fig. 1 Null effect of uridine on basal synaptic transmission. a Left, representative input-output (I-O) experiments for uridine (300 μM) and control;with the amplitude of the fiber volley (FV) as the independent variable and the slope of the fEPSP as the d
Fig. 2 Null effect of uridine on short-term synaptic plasticity. aRepresentative traces showing paired pulse stimulation at inter-pulseintervals (IPI) of 50 ms and 100 ms from brain slices treated withhigh uridine (300 μM)
Fig. 3 Concentration-dependent effect of uridine on the induction of long-term potentiation
Fig. 4 Uridine decreases NMDAR-mediated synaptic responses. a Representative single theta-burst stimulation (TBS) event during LTP induction.Shaded areas indicate the total depolarization measured
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