• No results found

Design and elaboration of a tractable tricyclic scaffold to synthesize druglike inhibitors of dipeptidyl peptidase 4 (DPP 4), antagonists of the C–C Chemokine Receptor Type 5 (CCR5), and highly potent and selective phosphoinositol 3 Kinase δ (PI3Kδ) inhib

N/A
N/A
Protected

Academic year: 2020

Share "Design and elaboration of a tractable tricyclic scaffold to synthesize druglike inhibitors of dipeptidyl peptidase 4 (DPP 4), antagonists of the C–C Chemokine Receptor Type 5 (CCR5), and highly potent and selective phosphoinositol 3 Kinase δ (PI3Kδ) inhib"

Copied!
21
0
0

Loading.... (view fulltext now)

Full text

Loading

Figure

Figure 2. DPP-4 inhibitors (1−4), existing as a 1:1 mixture of either cis- or trans-diastereoisomers.
Table 1. DPP-4 Inhibitory Activitya
Figure 4. (a) Analytical chiral HPLC analysis of theseparated, eutomer final mixture of products, containing 2 (93%) and 1 (7%); (b) sample spiked with the previously 1
Figure 5. (a) Sitagliptin (magenta) in DPP-4 (PDB code 1X70); (b)DPP-4.eutomer 1 docked into DPP-4; (c) diastereoisomer 2 docked into26
+7

References

Related documents

However, in a dramatic turn of events, in August of 2000, under pressure from Palestinian negotiators in the Israeli-Palestinian peace process, Israeli officials

In my opinion, this practical point, should be recognized even though by definition any sale of chattel paper or accounts, even with- out recourse, is a security

landscape analyses pioneered by the British after· With the exception of Leone's materialist anal- World War II (Fowler 1972): Logically, this was ysis of Maryland

Fig 1: In-vitro release profile of formulations 3.4 Drug polymer interaction study. The drug - excipient interaction were studied

ANC: African National Congress; CMHF: Cape Metro Health Forum; CMHF Executive: Cape Metro Health Forum Executive; DHS: District Health System; Draft Policy: Draft Policy Framework

The measurement of carotid intima-media thickness (cIMT) and plaques in B-mode ultrasound has become a tool for vascular risk prediction, as the relationship between IMT,

The purpose of this study was to determine whether end-tidal carbon monoxide (CO) corrected for ambient CO (ETCOc), as a single mea- surement or in combination with serum

ELBW, extremely low birth weight; NEC, necrotizing enterocolitis; IUGR, intrauterine growth-restricted; RER, respiratory exchange ratio; LA, linoleic acid; EFA, essential fatty