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Exploration of peptide T7 and its derivative as integrin αvβ3-targeted imaging agents

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Figure

Figure 1 radiochemistry and stability assay by Tlc scan.Notes: (A) [99mTcO4]-, rcP =98%; (B) 99mTc-T7, rcP =92.1%; (C) 99mTc-T7-6h, rcP =91%; (D) 99mTc-T7 in saline for 8 hours at 37°c, rcP 90%; (E) 99mTc-T7 in serum for 8 hours at 37°c, rcP 90%; (F) 99m
Figure 2 Flow cytometry analysis of integrin αvβ3 expression in eleven cell lines.Note: This experiment was repeated twice.
Table 1 The biodistribution of 99mTc-T7 in the nci-h157 model (%iD/g ± sD) (n=5)
Table 2 The biodistribution of 99mTc-T7-6h in the nci-h157 model (%iD/g ± sD) (n=5)

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