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Antisense oligonucleotide treatment ameliorates IFN-γ–induced proteinuria in APOL1-transgenic mice

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Figure

Figure 1. Genomic APOL1Schematic of the human location of the 2 point mutations that constitute the G1 genotype
Figure 2. IFN-γAPOL1 induces kidney APOL1 expression in APOL1 G0 and G1 mice, but proteinuria only in G1 mice
Figure 3. IFN-γevaluate G1 mouse kidneys 48 hours after IFN- induces kidney APOL1 expression in podocytes and endothelial cells in the kidney
Figure 4. IONIS-APOL1RxAPOL1with IONIS-APOL1PBS control. All data are presented as mean ± SD
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