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CF airway smooth muscle transcriptome reveals a role for PYK2

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Figure

Figure 1. Loss of CFTR leads to alterations in the airway smooth muscle transcriptome.of greater than or equal to 1 are denoted by orange symbols
Figure 2. Proteomic changes parallel transcriptional alterations in response to CFTR loss
Figure 3. Connectivity mapping can be used to generate therapeutic targets based upon the CF airway smooth muscle transcriptional signature
Figure 4. PYK2 but not ALK is present in airway smooth muscle. (A) Relative expression of PYK2 and ALK in WT and CFTR−/− airway smooth muscle tissue measured by RNA-seq in fragments per kilobase of transcript per million mapped reads (FPKM)
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