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Effects of polymer molecular weight on relative oral bioavailability of curcumin

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Figure 1 Morphology by transmission electron microscopy of curcumin nanoparticles. (A) LMw-NPC and (B) HMw-NPC.Abbreviations: LMw-NPC, curcumin encapsulated in low molecular weight PLgA; HMw-NPC, curcumin encapsulated in high molecular weight PLgA.
Figure 2 HPLC chromatograms of (acid (as internal standard); peak 2, curcumin.Abbreviation:A) blank plasma, (B) blank feces, (C) blank urine, (D) blank serosal fluid, (E) blank sac tissue, (F) plasma sample obtained from the jugular vein at 30 minutes afte
Figure 4 Cumulative excretion of curcumin in (A) feces and (B) urine after oral administration of curcumin at 1 g/kg, and LMw-NPC and HMw-NPC at 50 mg/kg (mean ± standard error, n = 4)
Table 3 Amount of curcumin in sections of the small intestine after incubation of curcumin, LMw-NPC, and HMw-NPC for  60 minutes

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