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Distinct Genetic Backgrounds in QuantitativeTraits Preceding Type 2 Diabetes: One Reasonfor Missing Heritability

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Figure

Fig. 1. A sequence of pre-diabetic phenotypes interacting with genetic and epigeneticresistance but the biochemical relationships are complex and bidirectional
Fig. 2. Quantitative traits (QTs) with different genetic backgrounds precede and, andarriving at the destination (T2D), is indicated in parentheses to the left of the diagramsince most of the T2D-associated variants affect β-cell metabolism
Table 1. Established genetic determinants of the traits preceding type 2 diabetes

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