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Codelivery of doxorubicin and triptolide with reduction-sensitive lipid–polymer hybrid nanoparticles for in vitro and in vivo synergistic cancer treatment

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Academic year: 2020

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Figure

Figure 1 The schematic drawing of dual drug-loaded lPNPs.Abbreviations: DOX, doxorubicin; lPNPs, lipid–polymer hybrid nanoparticles; mPeg-S-S-c16, monomethoxy-poly(ethylene glycol)-S-S-hexadecyl; Plga, poly(d,l-lactide-co-glycolide); TPl, triptolide.
Figure 2 (A) cytotoxicity of DOX-based combinations (DOX/TPl-1/0.05, 1/0.1, 1/0.2, 1/0.5, and 1/1) against KB cells after incubation for 48 h (n=4)
Figure 3 cI values at eD50 of DOX-based combinations (DOX dosage was 200 ng/ml).Abbreviations: cI, combination index; eD50, 50% effective dose; DOX, doxorubicin; TPl, triptolide.
Figure 4 TeM image of DOX/TPl-loaded lPNPs.Abbreviations: DOX, doxorubicin; lPNPs, lipid–polymer hybrid nanoparticles; TeM, transmission electron microscopy; TPl, triptolide.
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