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SUPPA2: fast, accurate, and uncertainty aware differential splicing analysis across multiple conditions

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Figure

Fig. 1 Overview of SUPPA2 differential splicing and timeserved |tion is calculated from events with similar associated expression.Theage transcript abundance (cDEXSeq in the differential splicing analysis between two conditions,with three replicates each [
Fig. 2 Accuracy analysis with simulated data.bdifferent sequencing depths ( a Proportion of events measured by each method (y-axis) from the 277 positive simulated cassetteevents at different sequencing depths (x-axis), from 120 million (120M) down to five
Fig. 3 Experimental validation of differentially splicing predictions by SUPPA2.calculated as the proportion of the detected events that was found as significant by each method: SUPPA2 (1/31), rMATS (2/35), MAJIQ (2/36),DEXSeq(2/25).that were only predicte
Table S15). For a maximum reachability distance of 0.11,

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