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Editing inducer elements increases A to I editing efficiency in the mammalian transcriptome

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Academic year: 2020

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Figure

Fig. 1 Structural requirements for efficient editing at the Q/R site of the GluA2 transcript
Fig. 2 The EIE of GluA2 can induce editing at the IM site in Gabra-3. a The wild-type Gabra-3 construct (G3 I/M) showing the short stem structureformed at the edited I/M site (red dot) and the EIE (in grey); the G3 I/M-ΔEIE mutant were the EIE has been del
Fig. 3 Selectivity of editing at the Q/R site in GluA2.HEK293 cells.expression vector in HEK293 cells.indicated with aADAR2-EAA-E488Q in HEK293 cells
Fig. 4 Structural requirements for efficient editing at the Q/R site in the GluK2 transcript.position of the EIE.formed in the vicinity of the Q/R site
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