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Systems epigenomics inference of transcription factor activity implicates aryl hydrocarbon receptor inactivation as a key event in lung cancer development

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Figure

Fig. 1 The SEPIRA algorithm and application to smoking and lung cancer. a The first step involves construction and validation of a tissue-specificregulatory network using the SEPIRA algorithm
Fig. 2 (See legend on next page.)
Table 1 The 38 lung-specific TFs in LungNet and their differential activity characteristics
Fig. 3 Integration of LungNet with promoter DNAm patterns.sum tests. a Color bars indicate the mean relative TF activity for the 38 lung-specific TFs asestimated in the Illumina 450 k DNAm dataset for lung tissue and all other tissues combined
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