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Diverse interventions that extend mouse lifespan suppress shared age associated epigenetic changes at critical gene regulatory regions

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Academic year: 2020

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Figure

Fig. 1 The epigenomes of wild-type and Ames dwarf mice diverge with age. a Global percentage methylation per liver sample, for 2-month-old
Fig. 2 (See legend on next page.)
Fig. 3 Hypomethylated aDMRs are enriched at intragenic enhancers in highly expressed liver-specific genes.hypomethylated aDMRs, ±5 kb
Fig. 4(ChIP-seq) is indicated.173-fold,Q1 = highest, Q4 = lowest). Unexpressed genes (FPKM = 0) are given (rows), showing WT (redbivalent regions in WT mice
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