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Cross enhancement of ANGPTL4 transcription by HIF1 alpha and PPAR beta/delta is the result of the conformational proximity of two response elements

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Figure

Figure 1 Endothelial cell migration is synergistically enhanced by hypoxia and the PPARstimulus at 0 hour and 8 hours
Figure 2 Genome-wide analysis of PPARβ/δ and/or hypoxia-induced genes in endothelial cells identified ANGPTL4 as the commontarget gene
Figure 3 ChIP-seq analysis (H3K4me1, H3K4me3, HIF1reporter assay.α, PPARβ/δ, H3K27ac) of the ANGPTL4 gene and construct design for the The displayed enrichment scores for ChIP-seq were calculated by QuEST and visualized with IGB software (Affymetrix)
Figure 4 (See legend on next page.)
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