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Tumor driven by gain-of-function HER2 H878Y mutant is highly sensitive to HER2 inhibitor

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Figure

Figure 1: HER2 H878Y is sensitive to HKI-272. A. HER2 stable cell lines were treated with 500nM HKI-272 for 30 minutes, and then subjected to immunoblotting for detecting HER2 downstream signalings
Figure 2: H878Y mutant HER2 is tumorigenic in vivo. A. A representative H&E image of lung tumor of H878Y transgenic mice
Figure 3: HER2 H878Y driven lung tumor depends on continuous expression of transgene for maintenance
Figure 4: HER2 H878Y-driven lung tumor is sensitive to HKI-272 treatment. A. HKI-272 treatment led to regression of lung tumor in transgenic mice
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