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ErbB-3 activation by NRG-1β sustains growth and promotes vemurafenib resistance in BRAF-V600E colon cancer stem cells (CSCs)

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Academic year: 2020

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Figure

Figure 1: Effect of growth factors on wild-type and V600E-BRAF mutated colon CSCs. A. Cell proliferation was determined in wild-type (left panel) and BRAF mutant cells (right panel) in the presence or absence of growth factors (EGF and bFGF) by Cell Titer-
Figure 2: NRG-1β sustains proliferation of colon CSCs and reverts Vemurafenib antitumor effects
Figure 3: ErbB-3 is required for NRG-1β-dependent escape to Vemurafenib. A. Immunoblot analysis of total and phosphorylated of ErbB-3 receptor and downstream signaling pathways evaluated in CC09 cells silenced for ErbB-3 (shErbB-3) as compared to same cell
Figure 4: Treatment with anti-ErbB-3 antibody results in delay of V600E-BRAF tumor growth

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