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Regulation of bone mass by Wnt signaling

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Figure

Figure 1Elements of Wnt/β-catenin signaling. In the liganded state, binding of Wnt to the frizzled receptor inhibits GSK3 activity through mechanisms involv-ing Axin, Frat-1, and Disheveled (Dsh)
Figure 2Wnt/-catenin signaling regulates osteogenesis through multiple mechanisms. Wnts repress alternative mesenchymal differentiation pathways

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