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Wnt proteins contribute to neuromuscular junction formation through distinct signaling pathways

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Figure

Fig. 1. Wnt4 and Wnt11 cooperatively enhance AChR clustering in vitromyotube differentiation at three muscle stages: T1, myotube formation; T2, visualization of AChR clusters; and T3, late muscle differentiation
Fig. 2. Wnt4 and Wnt11 cooperate to enhance AChR clustering andpresynaptic axon outgrowthUcondition
Fig. 3. Loss of Wnt function impairs NMJ formation. (A) Confocal images ofwhole-mount left hemidiaphragms from E14 WT and Wnt11−/− embryos
Fig. 4. Wnt4 and Wnt11 signal throughthe canonical pathway to elicit AChR(ns): compared with untreated conditions.nWhitneyScale bars: 10 µm in E; 20 µm in G;subunit mRNA expression in myotubestreated or otherwise with Wnt4 (10 ng/ml)and/or Wnt11 (10 ng/ml)
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