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Ataxia telangiectasia and Rad3-related inhibitors and cancer therapy: where we stand

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Academic year: 2020

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Figure

Fig. 1 Replication stress induced ATR-CHK1 activation. ATR is activated by replication protein A (RPA)-coated single-stranded DNA (ssDNA) thatarises at stalled replication fork or resected DNA double-strand break (DSB), particularly at ssDNA and double-str
Table 1 Summary of ATR inhibitor-based clinical trials

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