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<p>DNA-PKcs Mediates An Epithelial-Mesenchymal Transition Process Promoting Cutaneous Squamous Cell Carcinoma Invasion And Metastasis By Targeting The TGF-β1/Smad Signaling Pathway</p>

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Figure

Figure 1 DNA-PKcs expression was signivivo. *in cSCC. (DNA-PKcs was upregulated in the cSCC cell line SCL-1
Figure 2 DNA-PKcs increased the migration and invasion of cSCC cells and promoted EMT
Figure 3 TGF-β1 induced SCL-1 cell EMT and promoted the activation of DNA-PKcs. (A) Compared with control cells, SCL-1 cells treated with 5 ng/mL TGF-β1 for 48 hexhibited a spindle-shaped, fibroblast-like morphology with mesenchymal phenotypic changes
Figure 4 DNA-PKcs promoted EMT and invasion partly via TGF-In addition, the knockdown of DNA-PKcs decreased the p-Smad3 levels

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