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Thrombolytic Activity, Drug Likeness Property and ADME/T Analysis of Isolated Phytochemicals from Ginger (Zingiber officinale) Using In Silico Approaches

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Figure

Figure 1. The mechanism of action of tPA in fibrinolysis inside the blood vessel. tPA gradation product (FDP) ultimately removing the blood clot
Figure 2. Chemical structures of (1) Gingerol (PubChem CID: 442793), (2) Beta-sitosterol (PubChem CID: 222284), (3) Isovanillin (PubChem CID: 12127) and (4) 2,6-Dimethyl- 2-octene-1,8-diol (PubChem CID: 13498523)
Figure 3. 3D representation of tPA (PDB ID: 1A5H) in its native li-gand bound form. Four chains of tPA are represented in ribbon style and ligands are represented in stick style
Figure 4. 2D representation of the best pose interaction between (1) Gingerol (PubChem sphere
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