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Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo

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Academic year: 2020

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Figure

Figure 1GW4064 activates FXR in colonic epithelial cells. (A) Monolayers of Tin nuclear and cytosolic fractions was measured after 3, 6 or 24 h
Figure 2FXR activation inhibits colonic epithelial Clexposed to GW4064 at various concentrations for 24 h before Clwere exposed to OCA at various concentrations for 24 h before ClCCh-induced inhibition of NHE3 activity were measured as changes in BCECFwere
Figure 3FXR activation inhibits colonic epithelialcontribution of ENaC to observed I(intraperitoneal, 50 mg/kg), or vehicle, for 24 h after which muscle-stripped sections of distal colon were mounted in Ussing chambers formeasurements of CCh (100 fluid and
Figure 4FXR activation decreases Nashows densitometric analysis of three similar experiments
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