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Acute exacerbations of chronic obstructive pulmonary disease are associated with decreased CD4+ & CD8+ T cells and increased growth & differentiation factor-15 (GDF-15) in peripheral blood

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Figure

Table 1 Summary of demographics, spirometry, smoking history and medications 1
Fig. 1 AE-COPD confirmed by increases in BCSS total score and serum CRP levels. AE-COPD events were identified by physician diagnosis (after exclusion of pneumonia by chest radiograph) plus the clinical decision to prescribe oral steroids or antibiotics.
Fig. 2 Peripheral blood CD4+ and CD8+ T cells decreased during AE-COPD while CD15+ granulocytes increased
Fig. 3 Representative graphs from individual subjects tracking percentages of CD4+ and CD8+ T cells during stable and exacerbation visits
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