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Coiled-coil mediated liposomal fusion: Asymmetric behaving peptide fusogens

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Figure 1. Stages of the fusion cascade. Membranes are brought in close apposition (I) and approach each other in a point-like protrusion (II)
Figure 3. Schematic representation of (A) coiled-coil structure between peptides E and K, (B) targeted liposome fusion mediated by coiled-coil formation between CPE 4 modified liposomes and CPK 4 modified liposomes, (C) CD spectra of CPE 4 modified
Table 1. Overview of the derivatives of peptides E and K used in this study.
Figure 5. Content mixing between E and K-decorated liposomes as a function of PEG spacer length (m/n) as indicated by an increase in sulforhodamine B emission after 30 min
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L IPOPEPTIDE SYNTHESIS R EFERENCES IRRAS MEASUREMENTS A MIDE I’ BAND FITTING F ITTING OF ANGLE DEPENDENT A MIDE I’ IRRAS BANDS F ITTING PROCEDURE OF S POLARIZED A MIDE I’ IRRAS BANDS F UTURE WORK L IPID MIXING F USION EFFICIENCY S TRUCTURE ACTIVITY RELATIONSHIP OF FUSOGENS C ONTENT MIXING

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