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Mapping in vivo target interaction profiles of covalent inhibitors using chemical proteomics with label-free quantification

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Figure

Figure 1 | Chemical proteomics workflow with inhibitor and probes used in this study. (a) General activity-based probe (ABP) design, illustrated with FP- FP-biotin Orange: trap (fluorophosphonate)
Figure 2 | Results of the competitive ABPP experiment in mice with DH376 and the probe cocktail, with hierarchical clustering of probe targets
Figure 3 | Protein and peptide abundance data for selected probe targets. (a) Normalized protein abundance for Dagla, Abhd6, Ces1c and Mgll in different  conditions

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