Consensus conference on salivary gland tumors

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Consensus conference

on salivary gland tumors

October 23rd-24th 2014, School of Medicine, University of Brescia (Italy)

Adenoid-cystic carcinoma and high-grade neoplasms

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Dear Colleagues,

The challenging management of salivary gland malignancies asks for a multidisciplinary approach. In the last few years the knowledge in the field of basic science has grown rapidly, and is probably becoming the driver for therapeutic choices in the future. In keeping with this concept, the present conference wants to gather experts in the fields of Pathology, Imaging, Surgery (ENT and Maxillo-Facial Surgeons), Radiation and Medical Oncology to prepare for the future. Together we will delineate by consensus the management of “problematic” salivary gland tumors for the next years.

This will be a 2-day consensus conference, with the first day dedicated to adenoid-cystic carcinoma, and the second day focused on high-grade salivary gland malignancies. Three topics for discussion (diagnosis, therapeutic approach to the primary lesion, treatment of recurrent/metastatic disease) will characterize each day of the meeting. Each session will consist of two parts: in the first, the “state of the art” will be defined by experts, whereas in the second part the panelists and audience will try to reach a consensus.

For each topic (diagnosis, treatment of primary tumor and metastatic disease), a chairman and experts will be identified. They will be in charged of writing a document that will be submitted to the panelists for comments, at least 6 months before the date of the meeting. The final document will be discussed during the meeting between experts and the audience to reach a consensus.

Consensus conference on salivary gland tumors

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Congress Directors

Adel El-Naggar, Department of Pathology, M.D. Anderson Cancer Center, Houston, USA Ehab Hanna, Department of Head and Neck Surgery, M.D. Anderson Cancer Center, Houston, USA

Lisa Licitra, Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

Roberto Maroldi, Department of Radiology, University of Brescia, Italy Piero Nicolai, Department of Otorhinolaryngology, University of Brescia, Italy

Scientific Secretariat

Laura Locati, Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

Davide Lombardi, Department of Otorhinolaryngology, University of Brescia, Italy Ester Orlandi, Department of Radiation Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

William Vermi, Department of Pathology, University of Brescia, Italy

The meeting will be held under the auspices of

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International Faculty

Ian Casselman, Department of Radiology, A.Z. St.-Jan Hospital, Bruges, Belgium Jurgen Debüs, Department of Radiation Oncology, University of Heidelberg, Germany Isabel Fonseca, Serviço de Anatomia Patológica, Instituto Português de Oncologia Francisco Gentil, Lisboa & Instituto de Anatomia Patológica, Faculdade de Medicina de Lisboa, Portugal

Nicole J.M. Freling, Radiology Department, Academic Medical Centre, Amsterdam, The Netherlands

David G. Pfister, Head and Neck Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, USA

Goran Stenman, Department of Pathology, Sahlgrenska Cancer Center, University of Göteborg, Sweden

Carla M. van Herpen, Department of Medical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

Vincent Vander Poorten, Department of Head Neck Surgery, University of Leuven, Belgium

Philippe Vielh, Department of Pathology, Institut Gustave Roussy, Paris, France Randal Weber, Department of Head Neck Surgery, Houston, USA

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Italian Faculty

Mario Airoldi, Department of Medical Oncology, University of Turin

Antonino R. Antonelli, Department of Otorhinolaryngology, University of Brescia Alfredo Berruti, Department of Medical Oncology, University of Brescia

Francesco Bertagna, Department of Nuclear Medicine, University of Brescia Bernardo Bianchi, Department of Maxillofacial Surgery, University of Parma Mario Bussi, Department of Otorhinolaryngology, University “S.Raffaele”, Milan Flavio Crippa, Nuclear Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan Fabio Facchetti, Department of Pathology, University of Brescia

Carlo Fallai, Department of Radiation Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

Davide Farina, Department of Radiology, University of Brescia

Piero Fossati, Department of Radiation Oncology, National Center for Adrotherapy “CNAO”, Milan

Raffaele Giubbini, Department of Nuclear Medicine, University of Brescia

Gioacchino Giugliano, Department of Head and Neck Surgery, Istituto Europeo di Oncologia, Milan

Marco Guzzo, Head and Neck Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan Stefano Magrini, Department of Radiation Oncology, University of Brescia

Ugo Pastorino, Thoracic Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan Cesare Piazza, Department of Otorhinolaryngology, University of Brescia

Giuseppe Sanguineti, Department of Radiation Oncology, National Cancer Institute “Regina Elena”, Rome

Enrico Sesenna, Department of Maxillofacial Surgery, University of Parma

Giuseppe Spriano, Department of Head and Neck Surgery, National Cancer Institute “Regina Elena”, Rome

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07.15-07.55 Registration

08.00-08.10 Welcome and Introduction

08.10-08.25 Honorary lecture: The history of adenoid-cystic carcinoma A. R. Antonelli

Day 1, October 23rd 2014:

Adenoid-cystic carcinoma (ACC)

08.25-08.45 Lecture in tribute to Marina Speck:

Overview on molecular features of ACC and their impact on treatment. (A. El-Naggar) (20’)

08.45-09.50 1st Session: DIAGNOSIS President: F. Chiesa Chairman: A. El-Naggar

Panelists: I. Casselman, F. Crippa, F. Facchetti

- MYB and MYB-NFIB as diagnostic and therapeutic targets in ACC (G. Stenman) (15’) - FNAB and histology: the most frequent missclassifications (I. Fonseca) (10’) - Overview on perineural spread: cellular and molecular mechanisms (W. Vermi) (10’) - The role and limits of imaging (CT, MRI, and PET) in treatment planning (R. Maroldi- R. Giubbini) (25’)

09.50-10.45 Consensus on: - Histopathologic diagnostic criteria - Diagnostic imaging

10.45-11.00 Coffee-break

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11.00-12.30 2nd Session: TREATMENT OF THE PRIMARY LESION President: G. Paludetti

Chairman: V. Vander Poorten

Panelists: P. Fossati, G. Giugliano, S. Magrini, L. Licitra, D. Lombardi - Indications, suggestions and problems in surgical treatment of minor salivary glands adenoid-cystic carcinoma (P. Nicolai) (15’)

- Indications, suggestions and problems in surgical treatment of major salivary glands adenoid-cystic carcinoma (E. Hanna) (15’)

- Reconstructive issues and facial reanimation (C. Piazza, E. Sesenna, B. Bianchi) (20’) - Indications to RT in an adjuvant and exclusive setting (+/- CHT) (E. Orlandi) (20’) - Carbon-ion therapy (J. Debüs) (20’)

12.30-13.45 Consensus on: - Treatment of the primary lesion - Reconstruction and facial reinnervation - Adjuvant and curative RT +/- CHT

13.45-14.45 Lunch

14.45-16.00 3rd Session: FOLLOW-UP AND RECURRENT/METASTATIC DISEASE President: G. Succo

Chairman: R. Weber

Panelists: E. Hanna, E. Orlandi, M. Airoldi, NJ.M. Freling, F. Bertagna - The role of imaging (CT, MRI and PET) in the post-treatment surveillance (I. Casselman) (15’) - The role of surgery in the treatment of local relapse (V. Vander Poorten) (15’) - The role of reirradiation in the treatment of local relapse (C. Fallai) (15’) - The role of surgery in the treatment of lung metastasis (U. Pastorino) (10’) - Therapy for locally advanced, recurrent and metastatic disease (D. G. Pfister) (20’)

16.00-18.00 Consensus on: - Follow-up strategy

- Indications for surgery and/or reirradiation for recurrent primary lesions - Indications for surgery for lung metastases

- Medical treatment for metastatic disease

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Day 2, October 24th 2014:

High-grade salivary gland tumors (High-grade MEC, Salivary duct

carcinoma, Carcinoma ex-pleomorphic adenoma, Adenocarcinoma)

08.00-08.20 Lecture Overview on molecular features of high-grade salivary gland tumors and their impact on treatment (A. El-Naggar) (20’)

08.20-09.35 1st Session: DIAGNOSIS President: M. Benazzo Chairman: F. Facchetti

Panelists: I. Casselman, R. Giubbini, A. El-Naggar, B. Valeri - Chromosomal rearrangements and fusion oncogenes (G. Stenman) (20’)

- The role of FNA in diagnosis and molecular testing of salivary gland cancers (P. Vielh) (15’) - Histopathologic definition and differential diagnosis (I. Fonseca) (15’)

- The role and limits imaging (CT, MRI and PET) in treatment planning (D. Farina - F. Crippa) (20’)

09.35-10.40 Consensus on: - Histopathologic diagnostic criteria - Diagnostic imaging

10.40-10.55 Coffee-break

10.55-11.50 2nd Session: TREATMENT OF THE PRIMARY LESION AND THE NECK President: M. De Vincentiis

Chairman: M. Bussi

Panelists: M. Guzzo, J. Debüs, A. Berruti, L. Locati

- Indications, suggestions, and problems in surgical treatment of high-grade salivary gland tumors (V. Vander Poorten) (15’)

- Indications, suggestions, and problems in surgical treatment of the neck in high-grade salivary glands tumors (G. Spriano) (15’)

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11.50-13.10 Consensus on:

- Surgical indications for the treatment of primary lesions and the neck - Indications for adjuvant treatment and exclusive RT (+/-ChT)

13.10-14.10 Lunch

14.10-15.10 3rd Session: FOLLOW-UP AND RECURRENT/METASTATIC DISEASE Chairman: L. Licitra

Panelists: E. Hanna, C. Fallai, R. Maroldi/D. Farina, F. Bertagna, F. Pia - The role of imaging in the post-treatment surveillance (NJ.M. Freling - F. Crippa) (15’) - The role of surgery in the treatment of loco-regional relapse (R. Weber) (15’) - The role of reirradiation in the treatment of loco-regional relapse (S. Magrini) (15’) - Systemic therapy for locally advanced, recurrent and metastatic disease (C. M. Van Herpen) (15’)

15.10-16.30 Consensus on: - Follow-up strategy

- Indications to surgery and/or re-irradiation for recurrent primary lesions - Systemic treatment for metastatic disease

16.30-17.00 Closing remarks

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October 23rd-24th 2014, School of Medicine, University of Brescia (Italy)

General informations

Language The official language will be English.

ECM/CME The Consensus Conference on salivary gland tumors Adenoid-cystic carcinoma and high-grade neoplasm “A common committment towards the future” has been granted for the CME accreditation by: Italy Ministry of Heatlh (E.C.M.) for Italian medical doctors: Oncology, Radiotherapy, Maxillo-facial surgery, Otorhinolaryngology, Anatomical pathology, Radiodiagnostic: 18 CME points.

European Accreditation Council for Continuing Medical Education (EACCME®). In evaluation for European medical doctors.

Hotel booking For information and booking please contact the Organizing Secretariat.

Course Venue School of Medicine - University of Brescia - Via Valsabbina, 19 - 25121 Brescia - Italy

Insurance

Organizers do not accept responsability for individual medical, travel or personal expenses. Registrants are strongly advised to take out their own personal insurance policies.

Cancellation Policy

In the unusual circumstance that the course is cancelled, two weeks notice will be given and the fee will be refunded in full. The Organizers are not responsible for any airfare, hotel or other costs incurred.

Organizing Secretariat

Servizi C.E.C. Srl - Via G. Verdi, 18 - 24121 Bergamo - Italy Phone +39.(0)35.249899 Fax. +39.(0)35.237852

e-mail: k.gissi@servizicec.it www.servizicec.it

How to reach the University of Brescia-School of Medicine By car Highway A4 Milano-Venezia.

Exit Brescia Ovest; at the exit follow Tangenziale Ovest proceed along Tangenziale Nord. Follow for Stadio or

Ospedale, proceed along via Oberdan. Go through, turn left for Via Triumplina and after 800 mt. turn right through Via Branze, on your left there’s the School of Engineering and on the right hand there is School of Medicine.

Exit Brescia Centro; at the exit take the Tangenziale Sud follow the road signs that take to

Tangenziale. Please follow the one with Val Trompia, Milano or Bergamo. Arrived in the Tangenziale, proceed along till the road sign Tangenziale Ovest or Val Trompia. Now drive thorugh Tangenziale Ovest and go ahead to Tangenziale Nord, follow the road signs Stadio or Ospedale. Keep driving on via Oberdan till the end, then turn left on Via Triumplina and after 800 mt. turn right through Via Branze, on your left there’s the School of Engineering and on the right hand there is School of Medicine.

By Train You can reach the School of Medicine via bus, subway or taxi

By Taxi The taxi stand is just outside the train station.

By Bus • Line 1: direction Mompiano, bus stop via Schivardi.

• Line 15: direction Villaggio Montini, bus stop Viale Europa, corner via Branze.

By Tube Blue line, stop at Europa

Parking Closed to the School of Medicine there are:

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October 23rd-24th 2014, School of Medicine, University of Brescia (Italy)

Registration form

Please, fill in this form and return it to Servizi C.E.C. Srl: by fax +39 035 237852 by mail k.gissi@servizicec.it First name (s)

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Pursuant to Italian Legislative Decree no. 196/03 (Privacy law), Servizi C.E.C. s.r.l. - Via Verdi, 18 - 24121 Bergamo - Italy – is responsible for the processing and collection of personal data.

You are free to conferm or deny this right but these data are necessary to supply the services required. You may address Servizi C.E.C. s.r.l. for the treatment and exert your rights pursuant to article 7 of the Italian Legislative Decree no. 196/03 (access, correction, cancellation, etc.).

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Registration fee

Full € 610,00 VAT included Resident 305,00 VAT included (*)

(*) must be accompanied by a letter from the applicant’s chief confirming the “Resident” status. Please send this confirmation by email to k.gissi@servizicec.it

Registrations must be sent to Organizing Secretariat completing the form accompanied by the payment of the fee.

The registration fee includes: entrance to the course, course materials, certificate of attendance, coffee breaks, lunches.

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October 23rd-24th 2014, School of Medicine, University of Brescia (Italy)

How to pay

BANK TRANSFER

Please fax a copy of the bank transfer to the Organizing Secretariat. Account name: SERVIZI C.E.C. S.r.l. Bank name: Credito Bergamasco IBAN code: IT96 E 03336 11101 000000000049 Swift code: CREBIT22 CREDIT CARD

Please fill in every line (write in capital letters), sign it and fax it to the Organizing Secretariat.

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* Only for Italian and EU participants.

** Only for Italian and EU participants.

PLEASE NOTE

• Only after receiving the payment and processing the request, the Organizing Secretariat will send you a confirmation letter in order to confirm your registration.

• Bank charges are the responsibility of the participant and should be paid at source in addition to the registration fee

• Registration fee includes VAT taxes • Only Euro (€) are accepted

• Requests by phone are not accepted

Cancellations/refunds/changes

• If a written request is received before August 29th, 2014 a 75% refund will be allowed.

After August 30tht, 2014 no refund is due. All refunds will be handled after the course and bank charges will be retained by the Organizing Secretariat.

• No shows will not be refunded. Name changes are accepted at any time and do not incur any additional fee.

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Organizing Secretariat

Servizi C.E.C. Srl

Via Verdi, 18 - 24121 Bergamo - Italy

Tel. +39.035.249899 Fax +39.035.237852 Mob. +39.339.6339391 k.gissi@servizicec.it www.servizicec.it

Consensus conference on salivary gland tumors

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