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The clinical promise of immunotherapy in triple-negative breast cancer

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Academic year: 2020

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Figure 1 General mechanisms and agents targeting immune checkpoints in TNBC. Notes: (A) Major immune cell players and interactions in the tumor microenvironment regulated by immune checkpoints
Figure 2 emerging immunotherapy targets and combinatorial agents in TNBC. Notes: Current trials focus on modulating the tumor microenvironment by increasing mutational burden in tumors, stimulating antigen-presenting cells, decreasing suppressive functions of Tregs, and targeting other negative immune checkpoints on effector T cells.Abbreviations: PAMP, pathogen-associated molecular pattern; PARP, poly-ADP ribose polymerase; TGFβ, transforming growth factor beta; TNBC, triple-negative breast cancer; Treg, regulatory T cell.
Table 1 Clinical trials using immunotherapy with neoadjuvant chemotherapy
Table 3 immunotherapy in combination with various agents under investigation in advanced triple-negative disease
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