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Clinical use of crizotinib for the treatment of non-small cell lung cancer

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Figure

Figure 1 Aberrant ALK signaling cascade.Notes: ALK gene rearrangements result in aberrant ALK signaling through Pi3K/AKT/mTOR, JAK/STAT, and RAS/MEK/ERK signaling pathways
Table 1 Efficacy data for approval by the US Food and Drug Administration24–26
Table 2 Common adverse events reported in studies A and B
Table 3 Serious adverse events requiring crizotinib dose modification
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