ﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ﯽﻤﻠﻋ ﻪﻠﺠﻣ مﻼﯾا ﯽﮑﺷﺰ هرود ﻢﻫﺪﻔﻫ هرﺎﻤﺷ ، مﻮﺳ ، ﺰﯿﯾﺎﭘ 88
ﺶﻫﺎﮐ رد قﺎﻤﺳ ﺮﺛا ﯽﺳرﺮﺑ
LDL
ﻦﯿﺗﺎﺘﺳﻮﻟ ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد لوﺮﺘﺴﻠﮐ
ﯽﻓﻮﺋر ﺮﯿﻣا 1 ، ﯽﻧادﺮﻣ زﺎﻨﻬﻣ، 2 غﺎﺒﺻ دﻮﻋﻮﻣ ، 3 نﺎﻔﻟد ماﺮﻬﺑ ، 4 ﯽﺣاﺮﻃ داﻮﺟ ﺪﻤﺤﻣ ، 5
1(
،ﺐﻠﻗ هوﺮﮔ
ﯽﮑﺷﺰﭘ هﺪﮑﺸﻧاد
،
نﺎﺘﺳﺮﻟ ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد
2(
ﯽﮑﺷﺰﭘ هﺪﮑﺸﻧاد ،ﻪﯾﺬﻐﺗ هوﺮﮔ
،
نﺎﺘﺳﺮﻟ ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد
3(
ﭘ يﻮﺠﺸﻧاد
ﯽﮑﺷﺰﭘ هﺪﮑﺸﻧاد ،ﯽﮑﺷﺰ
،
نﺎﺘﺳﺮﻟ ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد
4(
ﻮﻟﻮﮐﺎﻣرﺎﻓ هوﺮﮔ
ژ
ﯽﮑﺷﺰﭘ هﺪﮑﺸﻧاد ،ي
،
نﺎﺘﺳﺮﻟ ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد
5(
ﺖﺷاﺪﻬﺑ هﺪﮑﺸﻧاد ، رﺎﻣآ هوﺮﮔ
،
نﺎﺘﺳﺮﻟ ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد
:ﺖﻓﺎﯾرد ﺦﯾرﺎﺗ
15
/
9
/
87
شﺮﯾﺬﭘ ﺦﯾرﺎﺗ
:
17
/
5
/
88
و
يﺪﯿﻠﮐ يﺎﻫ هژا
:
قﺎﻤﺳ ،ﯽﻣﺪﯿﭙﯿﻟ ﺲﯾد ،ﻦﯿﺌﺗوﺮﭘﻮﭙﯿﻟ ،زوﺮﻠﮑﺳاوﺮﺗآ ،ﺐﻠﻗ ﮏﯿﻤﮑﺴﯾا يرﺎﻤﯿﺑ
* :لﻮﺌﺴﻣ هﺪﻨﺴﯾﻮﻧ نﺎﺘﺳﺮﻟ ﯽﮑﺷﺰﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ﯽﮑﺷﺰﭘ هﺪﮑﺸﻧاد ،ﻪﯾﺬﻐﺗ هوﺮﮔ
E-mail: mardanii@yahoo.com
هﺪﯿﮑﭼ
:ﻪﻣﺪﻘﻣ
ﺎﻧ و گﺮﻣ ﺐﺟﻮﻣ ﻪﺘﻓﺎﯾ ﻪﻌﺳﻮﺗ يﺎﻫرﻮﺸﮐ رد يﺮﮕﯾد يرﺎﻤﯿﺑ ﺮﻫ زا ﺶﯿﺑ ﺐﻠﻗ ﮏﯿﻤﮑﺴﯾا يرﺎﻤﯿﺑ
ﺖﺳا هﺪﺷ ﯽﻧاﻮﺗ
و
ﯽﺒﻠﻗ يﺎﻬﯾرﺎﻤﯿﺑ دﻮﺷ ﯽﻣ ﯽﻨﯿﺑ ﺶﯿﭘ .ﺪﯾﺎﻤﻧ ﯽﻣ ﻞﯿﻤﺤﺗ ﻪﻌﻣﺎﺟ و ﺎﻫ هداﻮﻧﺎﺧ ﻪﺑ ار ﯽﺘﻔﮕﻨﻫ يﺎﻫ ﻪﻨﯾﺰﻫ ﻪﻟﺎﺳ ﻪﻤﻫ
ﺎﺗ ﯽﻗوﺮﻋ
لﺎﺳ
2020
.ﺪﻫد ﯽﻣ ﺶﻫﺎﮐ سر دوز گﺮﻣو ﯽﻧاﻮﺗﺎﻧ ﻞﯿﻟد ﻪﺑ ار داﺮﻓا ﯽﺋارﺎﮐ ﻪﮐ ددﺮﮔ ﻞﯾﺪﺒﺗ ﯽﯾﺎﻬﯾرﺎﻤﯿﺑ ﻪﺘﺳد ﺮﺳ ﻪﺑ
ﻪﮐ ﺖﺳا نآ زا ﯽﮐﺎﺣ دﺪﻌﺘﻣ تﺎﻌﻟﺎﻄﻣ
رد ﺮﻄﺧ ﻞﻣاﻮﻋ ﻦﯾﺮﺘﻤﻬﻣ زا ﺎﻫ ﯽﺑﺮﭼ ﻢﺴﯿﻟﻮﺑﺎﺘﻣ و ﺎﻤﺳﻼﭘ يﺎﻫ ﻦﯿﺌﺗوﺮﭘﻮﭙﯿﻟ رد لﻼﺘﺧا
يﻻﺎﺑ عﻮﯿﺷ ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ .ﺪﺳر ﯽﻣ ﺮﻈﻧ ﻪﺑ يروﺮﺿ يﺮﻣا ﯽﻣﺪﯿﭙﯿﻟ ﺲﯾد نﺎﻣرد و لﺮﺘﻨﮐ ﻦﯾاﺮﺑﺎﻨﺑ .ﺖﺳا زوﺮﻠﮑﺳاوﺮﺗآ دﺎﺠﯾا
ﺳ ﯽﻧاﺪﯿﺴﮐا ﯽﺘﻧآ ﺮﺛا ﺮﺑ ﯽﻨﺒﻣ ﯽﺗﺎﺷراﺰﮔ و دﺎﺑآ مﺮﺧ رد ﯽﻗوﺮﻋ ﯽﺒﻠﻗ يﺎﻫ يرﺎﻤﯿﺑ
رد قﺎﻤﺳ ﺮﺛا ﯽﺳرﺮﺑ ﻪﻌﻟﺎﻄﻣ ﻦﯾا زا فﺪﻫ ،قﺎﻤ
ﺶﻫﺎﮐ
LDLﻦﯿﺗﺎﺘﺳﻮﻟ ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد لوﺮﺘﺴﻠﮐ
ﺪﺷﺎﺑ ﯽﻣ
.
شور و داﻮﻣ
:ﺎﻫ
ﯽﺳرﺮﺑ ﻦﯾا رد
86
ﯽﺒﻠﻗ يﺎﻫ يرﺎﻤﯿﺑ ﻪﺑ ﻼﺘﺒﻣ رﺎﻤﯿﺑ
،ﺐﻠﻗ ﺺﺼﺨﺘﻣ ﮏﺷﺰﭘ ﻂﺳﻮﺗ ﻪﮐ ﯽﻗوﺮﻋ
و دﻮﺑ هﺪﺷ ﺪﯿﯾﺎﺗ نﺎﻧآ يرﺎﻤﯿﺑ
LDLﺎﻤﯿﺑ ﺐﻠﻗ هﺎﮕﻧﺎﻣرد ﻪﺑ و ﻪﺘﺷاد ﺰﯿﻧ ﻻﺎﺑ
هدﺮﮐ ﻪﻌﺟاﺮﻣ دﺎﺑا مﺮﺧ ﺮﯾﺎﺸﻋ ياﺪﻬﺷ نﺎﺘﺳر
هوﺮﮔ و ﻦﯿﺗﺎﺘﺳﻮﻟ ﺎﺑ نﺎﻣرد ﺖﺤﺗ هوﺮﮔ ﮏﯾ .ﺪﻧﺪﺷ ﻢﯿﺴﻘﺗ هوﺮﮔ ود ﻪﺑ ﯽﻓدﺎﺼﺗ رﻮﻃ ﻪﺑ نارﺎﻤﯿﺑ .ﺪﻨﺘﻓﺮﮔ راﺮﻗ ﯽﺳرﺮﺑ درﻮﻣ ،ﺪﻧدﻮﺑ
ﺑ ﻦﯿﺗﺎﺘﺳﻮﻟ ﺎﺑ نﺎﻣرد ﺖﺤﺗ مود
ﻪ
زا ﺲﭘ .ﺪﻨﺘﻓﺮﮔ راﺮﻗ قﺎﻤﺳ هوﻼﻋ
3
هﺎﻣ
فﺮﺼﻣ
ادﺪﺠﻣ ،ﺮﻈﻧ درﻮﻣ ﯽﻧﺎﻣرد يﺎﻫوراد
LDL.ﺖﻓﺮﮔ راﺮﻗ ﯽﺳرﺮﺑ درﻮﻣ و يﺮﯿﮔ هزاﺪﻧا نﺎﻧآ مﺮﺳ لوﺮﺘﺴﻠﮐ
:ﺶﻫوﮋﭘ يﺎﻫ ﻪﺘﻓﺎﯾ
زا
86
،ﻪﻌﻟﺎﻄﻣ درﻮﻣ رﺎﻤﯿﺑ
28
و هﺪﺸﻧ يرﺎﮑﻤﻫ ﻪﻣادا ﻪﺑ ﺮﺿﺎﺣ ،ﻒﻠﺘﺨﻣ ﻞﯾﻻد ﻪﺑ رﺎﻤﯿﺑ
58
رﺎﻤﯿﺑ
ﻦﯿﮕﻧﺎﯿﻣ .ﺪﻨﺘﺷاد رﻮﻀﺣ ﻪﻌﻟﺎﻄﻣ نﺎﯾﺎﭘ ﺎﺗ
LDLﺐﯿﺗﺮﺗ ﻪﺑ ﻪﻠﺧاﺪﻣ زا ﻞﺒﻗ درﻮﻣ و ﺪﻫﺎﺷ هوﺮﮔ لوﺮﺘﺴﻠﮐ
82
/
141
و
52
/
171
دﻮﺑ
ﻪﺑ ﻪﻠﺧاﺪﻣ زا ﺲﭘ ﻪﮐ
7/
115
و ﺪﻫﺎﺷ هوﺮﮔ رد
45
/
141
درﻮﻣ هوﺮﮔ لوﺮﺘﺴﻠﮐ ﺢﻄﺳ ندﻮﺑ ﺮﺗﻻﺎﺑ ﻞﯿﻟد ﻪﺑ .ﺪﯿﺳر درﻮﻣ هوﺮﮔ رد
ﺢﻄﺳ ﺶﻫﺎﮐ ﻂﺳﻮﺘﻣ ،ﺪﻫﺎﺷ هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ
LDLﺢﻄﺳ ﺶﻫﺎﮐ ﺪﺻ رد و
LDLﻦﯿﮕﻧﺎﯿﻣ .ﺪﯾدﺮﮔ ﯽﺳرﺮﺑ هوﺮﮔ ود ﻦﯿﺑ
درﻮﻣ هوﺮﮔ رد ﺶﻫﺎﮐ
07
/
30
)
17
(ﺶﻫﺎﮐ ﺪﺻرد
ﮔ رد و
ﺪﻫﺎﺷ هوﺮ
12
/
26
)
18
(ﺶﻫﺎﮐ ﺪﺻرد
ﺮﻈﻧ زا فﻼﺘﺧا ﻦﯾا ﻪﮐ دﻮﺑ
دﻮﺒﻧ راد ﯽﻨﻌﻣ يرﺎﻣآ
(P=٠٫٥٤) .:يﺮﯿﮔ ﻪﺠﯿﺘﻧ و ﺚﺤﺑ
ﺢﻄﺳ ﺶﻫﺎﮐ ﺚﻋﺎﺑ ﺪﻨﭼﺮﻫ قﺎﻤﺳ فﺮﺼﻣ ﺖﻔﮔ ناﻮﺗ ﯽﻣ ،ﻖﯿﻘﺤﺗ ﻦﯾا ﺞﯾﺎﺘﻧ سﺎﺳا ﺮﺑ
.ﺪﺷﺎﺑ ﯽﻤﻧ راد ﯽﻨﻌﻣ يرﺎﻣآ ﺮﻈﻧ زا ﺮﯿﺛﺎﺗ ﻦﯾا ﯽﻟو ،ددﺮﮔ ﯽﻣ مﺮﺳ لوﺮﺘﺴﻠﮐ
51ﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ﯽﻤﻠﻋ ﻪﻠﺠﻣ مﻼﯾا ﯽﮑﺷﺰ هرود ﻢﻫﺪﻔﻫ هرﺎﻤﺷ ، مﻮﺳ ، ﺰﯿﯾﺎﭘ 88
ﻪﻣﺪﻘﻣ
ﻪﺘﻓﺮﺸﯿﭘ نﺎﻬﺟ رد گﺮﻣ هﺪﻤﻋ ﺖﻠﻋ زوﺮﻠﮑﺳاوﺮﺗآ
ﺎﺗ دﻮﺷ ﯽﻣ ﯽﻨﯿﺑ ﺶﯿﭘ و ﺖﺳا
25
ﺖﻠﻋ ﻪﺑ ،هﺪﻨﯾآ لﺎﺳ
ﺰﯿﻧ ﻪﻌﺳﻮﺗ لﺎﺣ رد يﺎﻫرﻮﺸﮐ رد ﺮﯿﻣ و گﺮﻣ هﺪﻤﻋ
ﺪﺒﺗ
ﺎﮑﯾﺮﻣآ هﺪﺤﺘﻣ تﻻﺎﯾا رد .ددﺮﮔ ﻞﯾ
آ ،
زوﺮﻠﮑﺳاوﺮﺗ
ﻪﻧﻻﺎﺳ و هدﻮﺑ گﺮﻣ دراﻮﻣ مود ﮏﯾ زا ﺶﯿﺑ لﻮﺌﺴﻣ
لدﺎﻌﻣ يا ﻪﻨﯾﺰﻫ
100
ﻦﯾا نﺎﻣرد ﻪﺑ رﻻد نﻮﯿﻠﯿﺑ
ﻪﻧﻮﮔ
ﺪﺑﺎﯾ ﯽﻣ صﺎﺼﺘﺧا نارﺎﻤﯿﺑ
،)
1(
.
سﺎﺳا ﺮﺑ ﻦﯿﻨﭽﻤﻫ
لﺎﺳ رد ﺖﺷاﺪﻬﺑ ﯽﻧﺎﻬﺟ نﺎﻣزﺎﺳ شراﺰﮔ
2005
ود رد
دوﺪﺣ (دﺮﻣ و نز)ﺲﻨﺟ
17
ﻠﻋ ﻪﺑ ﺮﻔﻧ نﻮﯿﻠﯿﻣ
ــ
ﺖ
يرﺎﻤﯿﺑ
ﯽﺒﻠﻗ يﺎﻫ
-ﻓ ﯽﻗوﺮﻋ
ﻪﮐ ،ﺪﻧا هدﺮﮐ تﻮ
30
ﺪﺻرد
گﺮﻣ ﻞﮐ
ناﺮﯾا رد .ﺖﺳا هداد صﺎﺼﺘﺧا دﻮﺧ ﻪﺑ ار ﺎﻫ
ﺰﯿﻧ
38
ﺻرد
ــ
ﺪ
يﺎﻫ يرﺎﻤﯿﺑ زا ﯽﺷﺎﻧ گﺮﻣ دراﻮﻣ
ﯽﺒﻠﻗ
–
ﻪﺑ رﻮﺸﮐ ﺮﯿﻣ و گﺮﻣ ﺖﻠﻋ ﻦﯿﻟوا و ﺖﺳا ﯽﻗوﺮﻋ
دور ﯽﻣ رﺎﻤﺷ
،)
2(
.
ﻞﻣاﻮﻋ ،ﮏﯾژﻮﻟﻮﯿﻣﺪﯿﭘا تﺎﻌﻟﺎﻄﻣ
يرﺎﻤﯿﺑ زا ﻪﺘﺳد ﻦﯾا يازﺮﻄﺧ
رﺎﺸﻓ ،ﯽﻣﺪﯿﭙﯿﻟﺮﭙﯿﻫ ار ﺎﻫ
نﻮﺧ
ﺖﯿﻟﺎﻌﻓ و ﺲﻨﺟ ،ﻦﺳ ،ﺖﺑﺎﯾد ،رﺎﮕﯿﺳ فﺮﺼﻣ ،ﻻﺎﺑ
ﺪﻧا هدﻮﻤﻧ شراﺰﮔ ﯽﮑﯾﺰﯿﻓ يﺎﻫ
،)
3(
.
هﺪﺷ مﻼﻋا ﺰﯿﻧ
و ﺎﻤﺳﻼﭘ يﺎﻫ ﻦﯿﺌﺗوﺮﭘﻮﭙﯿﻟ رد لﻼﺘﺧا ﻪﮐ ﺖﺳا
زوﺮﺑ رد ﻞﻣاﻮﻋ ﺮﯾﺎﺳ زا ﺶﯿﺑ ،ﺎﻫ ﯽﺑﺮﭼ ﻢﺴﯿﻟﻮﺑﺎﺘﻣ
آ
دراد ﺶﻘﻧ زوﺮﻠﮑﺳاوﺮﺗ
،)
1،
4(
.
مﺮﺳ يﺎﻫﺪﯿﭙﯿﻟ ﻦﯿﺑ زا
ﺰﯿﻧ
LDLر طﺎﺒﺗرا ﻦﯾﺮﺘﺸﯿﺑ لوﺮﺘﺴﻠﮐ
ﺎﺑ ا
ا
راﺮﻘﺘﺳ
دراد زوﺮﻠﮑﺳاوﺮﺗآ
،)
2،
5(
.
نﺎﻣرد و لﺮﺘﻨﮐ اﺬﻟ
رد .ﺪﺳر ﯽﻣ ﺮﻈﻧ ﻪﺑ ﯽﺳﺎﺳا و مزﻻ يﺮﻣا ،ﯽﻣﺪﯿﭙﯿﻟﺮﭙﯿﻫ
وراد هوﺮﮔ ﺎﺘﺳار ﻦﯾا
ﯾ
يﺎﻫوراد ناﻮﻨﻋ ﻪﺑ ،ﺎﻫ ﻦﯿﺗﺎﺘﺳا ﯽ
ﭙﯿﻫ نﺎﻣرد ﺖﻬﺟ ﺐﺳﺎﻨﻣ
ـــ
ﺲﯾد و ﯽﻤﻟوﺮﺘﺴﻠﮐﺮ
ﺪﺷﺎﺑ ﯽﻣ ﺮﮕﯾد يﺎﻫ ﯽﻣﺪﯿﭙﯿﻟ
،)
4(
.
ﺞﯾﺎﺘﻧ ﻦﯿﻨﭽﻤﻫ
14
ا ﻪﻠﺧاﺪﻣ ﻪﻌﻟﺎﻄﻣ
يور ﺮﺑ ي
90056
رﺎﻤﯿﺑ
،
ﺮﮕﻧﺎﯿﺑ
ﺮﯿﺛﺎﺗ
ﺢﻄﺳ ﺶﻫﺎﮐ يور ﺮﺑ ﻦﯿﺗﺎﺘﺳا هوﺮﮔ يﺎﻫوراد راد ﯽﻨﻌﻣ
ﺖﺳا هدﻮﺑ نﺎﻧآ مﺮﺳ لوﺮﺘﺴﻠﮐ
ﻪﮐ
رد ﺶﻫﺎﮐ ﻦﯾا
ﺢﻄﺳ
LDLلوﺮﺘﺴﻠﮐ
نﺎﻧآ
قﺎﻔﺗا
ﺖﺳا هدﺎﺘﻓا
).
6،7
(
ﺮﯾد زا ،ﯽﺋﺎﯿﻤﯿﺷ يﺎﻫوراد ﺮﺑ هوﻼﻋ
زا هدﺎﻔﺘـﺳا زﺎﺑ
جاور نﻮـﺧ يﺎـﻫ ﯽـﺑﺮﭼ ﺶﻫﺎـﮐ ﺖﻬﺟ ﯽﺋوراد نﺎﻫﺎﯿﮔ
ﻪـﻄﺑار ﻦـﯾا رد ﻪـﮐ ﺖﺳا ﻪﺘﺷاد
ﯽـﻧاﺮﯾا ﯽﺘﻨـﺳ ﺐـﻃ رد
ﻤﺳ
ــ
زا هﺪـﻨﻨﮐ يﺮﯿﮕـﺸﯿﭘ هدﺎـﻣ ﮏـﯾ ناﻮـﻨﻋ ﻪـﺑ ار قﺎ
يرﺎﻤﯿﺑ
ﯽـﻀﻌﺑ ﺎـﺑ هاﺮـﻤﻫ و ﺪـﻧا ﻪﺘـﺴﻧاد ﯽﻣ ﯽﺒﻠﻗ يﺎﻫ
ﺼﻣ ﺎﻫاﺬــﻏ
ـــــ
ﺖــﺳا هﺪــﺷ ﯽــﻣ فﺮ
،)
8
.(
ﭽﻤﻫ
ــــ
ﻦﯿﻨ
ﯽﺳرﺮﺑ
ﺪـﻧا هداد نﺎـﺸﻧ قﺎﻤـﺳ يور ﺮﺑ هﺪﺷ مﺎﺠﻧا يﺎﻫ
ﻦﻧﺎﺗ ﯽﻬﺟﻮﺗ ﻞﺑﺎﻗ راﺪﻘﻣ ياراد قﺎﻤﺳ ﻪﮐ
رد ﻞـﺣ ﻞـﺑﺎﻗ
بآ
ﻪﮐ ﺖﺳا
ﺶﻘﻧ
ﯽـﺘﻧآ
ﯽﻧاﺪﯿـﺴﮐا
و ﻪﺘـﺷاد
ﺎـﻬﻨﺗ ﻪـﻧ
يﺎـﻫرﻮﻣﻮﺗ ﺪـﺿ ﻪـﮑﻠﺑ ﺖﺳا نﺎﻃﺮﺳ زا هﺪﻨﻨﮐ يﺮﯿﮕﺸﯿﭘ
ﺪﺷﺎﺑ ﯽﻣ ﯽﻧﺎﻃﺮﺳ
.)
11
-9(
ﯽﺳرﺮﺑ
ﺎﻫ
ﺰﯿﻧ
ا هداد نﺎﺸﻧ
ﺪﻧ
رد لﻮﻠﺤﻣ ﺖﻤﺴﻗ ﻪﮐ
آ
ﯽﺘﺑﺎـﻗر ﺮـﯿﻏ هﺪـﻨﻨﮐ رﺎـﻬﻣ ﮏـﯾ ناﻮـﻨﻋ ﻪﺑ ،قﺎﻤﺳ ب
ﺪﯿـﺴﮐاﺮﭘﻮﺳ لﺎـﮑﯾدار هﺪـﻨﻨﮐ ﻊـﻤﺟ و زاﺪﯿـﺴﮐا ﻦﯿﺘﻧاﺰﮔ
ﻠﺟ مﺮـﺳ لوﺮﺘﺴﻠﮐ ﺶﯾاﺰﻓا زا و ﺪﻨﮐ ﯽﻣ ﻞﻤﻋ
ـــ
يﺮﯿﮔﻮ
ﺪﻨﮐ ﯽﻣ
.)
15
-12
(
و ﯽﺋﺎﯿﻤﯿﺷ يﺎﻫوراد ﯽﺒﻧﺎﺟ ضراﻮﻋ ﻪﺑ ﻪﺟﻮﺗ ﺎﺑ
نآ ناﺮﮔ ﺖﻤﯿﻗ
ﻓ ،ﯽﻧازرا ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد ﺎﻫ
ـــ
ﻧاواﺮ
ـ
و ﯽ
ﻪﻌﻟﺎﻄﻣ ﻦﯾا زا فﺪﻫ ،ﯽﺋوراد نﺎﻫﺎﯿﮔ ندﻮﺑ ﺮﻄﺧ ﯽﺑ
يور ﺮﺑ قﺎﻤﺳ ﺮﺛا ﯽﺳرﺮﺑ
LDLنارﺎﻤﯿﺑ لوﺮﺘﺴﻠﮐ
ﯽﺒﻠﻗ
-
ﻗوﺮﻋ
نﺎﺘﺳرﺎﻤﯿﺑ ﺐﻠﻗ هﺎﮕﻧﺎﻣرد ﻪﺑ هﺪﻨﻨﮐ ﻪﻌﺟاﺮﻣ ﯽ
.دﻮﺑ دﺎﺑآ مﺮﺧ ﺮﯾﺎﺸﻋ ياﺪﻬﺷ
و داﻮﻣ
شور
ﺎﻫ
ﯽﻨﯿﻟﺎﺑ ﯽﺋﺎﻣزآ رﺎﮐ ترﻮﺻ ﻪﺑ ﻪﮐ ﻪﻌﻟﺎﻄﻣ ﻦﯾا رد
،ﺪﺷ مﺎﺠﻧا
نارﺎﻤﯿﺑ ﻪﯿﻠﮐ
40
-70
ﻪﻟﺎﺳ
)
86
زا ﻪﮐ (رﺎﻤﯿﺑ
ﻦﯾدروﺮﻓ لوا
1386
رﻮﯾﺮﻬﺷ نﺎﯾﺎﭘ ﺖﯾﺎﻐﻟ
1386
ﺲﯾد ﺎﺑ
)ﯽﻣﺪﯿﭙﯿﻟ
LDLﮕﻧﺎﻣرد ﻪﺑ (ﻻﺎﺑ
ياﺪﻬﺷ نﺎﺘﺳرﺎﻤﯿﺑ ﺐﻠﻗ هﺎ
هوﺮﮔ ود ﻪﺑ ﯽﻓدﺎﺼﺗ ترﻮﺻ ﻪﺑ ﺪﻧدﺮﮐ ﯽﻣ ﻪﻌﺟاﺮﻣ ﺮﯾﺎﺸﻋ
43
يﺮﻔﻧ
:ﺪﻧﺪﺷ ﯽﻣ ﻢﯿﺴﻘﺗ ﺮﯾز
1
-
.ﺪﻧدﺮﮐ ﺖﻓﺎﯾرد ﻦﯿﺗﺎﺘﺳﻮﻟ ﻪﮐ ﯽﻫوﺮﮔ
2
ـﺑ ﻦﯿﺗﺎﺘـﺳﻮﻟ ﻪـﮐ ﯽﻫوﺮﮔ
ﻪ
ﺖـﻓﺎﯾرد قﺎﻤـﺳ هوﻼـﻋ
.ﺪﻧدﺮﮐ
زود ﺎﺑ ﻦﯿﺗﺎﺘﺳﻮﻟ
20
ﻪـﻧازور مﺮـﮔ ﯽـﻠﯿﻣ
)
ﺎـﺑ هاﺮـﻤﻫ
داد نارﺎﻤﯿﺑ ﻪﺑ (مﺎﺷ ﯽﺋاﺬﻏ هﺪﻋو
ترﻮﺻ ﻪﺑ قﺎﻤﺳ .ﺪﺷ ه
رد ﻪـﮐ يرﻮـﺧ يﺎـﭼ ﻖﺷﺎﻗ ﮏﯾ لدﺎﻌﻣ مﺮﮔ ﮏﯾ ﻪﻧازور
قﺎﻤﺳ .ﺪﯾدﺮﮔ ﯽﻣ فﺮﺼﻣ ،ﺪﺷ ﯽﻣ ﻪﺘﺨﯾر بآ ناﻮﯿﻟ ﮏﯾ
.ﺪﺷ يراﺪﯾﺮﺧ ﻞﺤﻣ ﮏﯾ زا نارﺎﻤﯿﺑ ﻪﯿﻠﮐ ياﺮﺑ ﯽﻓﺮﺼﻣ
زا ﺲﭘ
3
،نﺎﻣرد عوﺮﺷ زا هﺎﻣ
LDLﺮﻫ رد لوﺮﺘﺴﻠﮐ
ﺎﺑ نآ ناﺰﯿﻣ و ﺪﺷ يﺮﯿﮔ هزاﺪﻧا ﺎﻫ هوﺮﮔ زا ﮏﯾ
ناﺰﯿﻣ
LDLﺘﺴﻠﮐ
ﯽﺋوراد ﻪﻠﺧاﺪﻣ زا ﻞﺒﻗ نارﺎﻤﯿﺑ لوﺮ
ﺪﯿﭙﯿﻟ ﯽﺘﻧآ يوراد نارﺎﻤﯿﺑ ﻪﻌﻟﺎﻄﻣ ﯽﻃ رد .ﺪﯾدﺮﮔ ﻪﺴﯾﺎﻘﻣ
ﺎﻫ ﻦﯿﺗﺎﺘﺳا فﺮﺼﻣ ﻪﻘﺑﺎﺳ و ﺪﻧدﺮﮐ ﯽﻤﻧ فﺮﺼﻣ يﺮﮕﯾد
نﻮﻣزآ هﺎﻣ ﺮﻫ نﺎﯾﺎﭘ رد ﺎﻨﻤﺿ .ﺪﻨﺘﺷاﺪﻧ ﺰﯿﻧ ار
يﺪﺒﮐ يﺎﻫ
نﺎﯾﺎﭘ رد .ﺪﺷ مﺎﺠﻧا نارﺎﻤﯿﺑ ﻪﯿﻠﮐ ﺖﻬﺟ
،ﻪﻠﺧاﺪﻣ
ﻦﯿﮕﻧﺎﯿﻣ
رﺎﯿﻌﻣ زا فاﺮﺤﻧا و
LDLو ﻪﺒﺳﺎﺤﻣ هوﺮﮔ ود لوﺮﺘﺴﻠﮐ
52ﺢﻄﺳ ﺶﻫﺎﮐ ﻂﺳﻮﺘﻣ ﺲﭙﺳ .ﺪﯾدﺮﮔ ﻪﺴﯾﺎﻘﻣ
LDLﺪﺷ ﻪﺒﺳﺎﺤﻣ هوﺮﮔ ود رد لوﺮﺘﺴﻠﮐ
يرﺎﻣآ ﺖﺴﺗ ﺎﺑ و
T-testهوﺮﮔ ود رد ﺶﻫﺎﮐ فﻼﺘﺧا
ﻞﯿﻠﺤﺗ و ﻪﯾﺰﺠﺗ درﻮﻣ
ﺖﻓﺮﮔ راﺮﻗ
.
ﺶﻫوﮋﭘ يﺎﻫ ﻪﺘﻓﺎﯾ
زا
86
ﺖﯾﺎﻬﻧ رد ﯽﺳرﺮﺑ درﻮﻣ رﺎﻤﯿﺑ
58
ﯽﻗﺎـﺑ ﺮـﻔﻧ
ﻌﺘﻣ ﻞﯾﻻد ﻪﺑ ﯽﻘﺑﺎﻣ و ﺪﻧﺪﻧﺎﻣ
ﺪﻧﺪﯾدﺮﮔ جرﺎﺧ ﻪﻌﻟﺎﻄﻣ زا دﺪ
ﺮﻫ رد داﺮﻓا داﺪﻌﺗ ﯽﺳرﺮﺑ نﺎﯾﺎﭘ رد اﺬﻟ و
ود زا ﮏﯾ
هوﺮـﮔ
درﻮـﻣ و ﺪﻫﺎﺷ
29
رﺎـﯿﻌﻣ فاﺮـﺤﻧا و ﻦﯿﮕﻧﺎـﯿﻣ .دﻮـﺑ ﺮـﻔﻧ
LDLﻪــﺑ ﻪــﻠﺧاﺪﻣ زا ﻞــﺒﻗ ﺪﻫﺎــﺷ هوﺮــﮔ رد لوﺮﺘــﺴﻠﮐ
ﺐﯿﺗﺮﺗ
82
/
141
و
39
/
28
زا ﺲﭘ ﻪﮐ دﻮﺑ
3
ﺖـﻓﺎﯾرد هﺎـﻣ
ﻪﺑ ﺐﯿﺗﺮﺗ ﻪﺑ ﻦﯿﺗﺎﺘﺳﻮﻟ
7/
115
و
13
/
34
رد .ﺪﯿـﺳر
هوﺮـﮔ
زا ﺰــﯿﻧ درﻮــﻣ
52
/
171
و
88
/
43
ﻪــﺑ ﻪــﻠﺧاﺪﻣ زا ﻞــﺒﻗ رد
45
/
141
و
69
/
34
ﺪﯿﺳر
.)
هرﺎﻤﺷ لوﺪﺟ
1(
هرﺎﻤﺷ لوﺪﺟ 1 . ﻦﯿﺗﺎﺘﺳﻮﻟ ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد ﻦﯿﺗﺎﺘﺳﻮﻟ ﺎﺑ نﺎﻣرد ﺖﺤﺗ داﺮﻓا ﻪﺑ طﻮﺑﺮﻣ يرﺎﻣآ يﺎﻫ ﺺﺧﺎﺷ ﺑ ﻪ ﻪﻠﺧاﺪﻣ زا ﺪﻌﺑ و ﻞﺒﻗ قﺎﻤﺳ هوﻼﻋ هوﺮﮔ ﻪﻠﺧاﺪﻣ شور داﺪﻌﺗ ﻦﯿﮕﻧﺎﯿﻣ ﺎﯿﻌﻣ فاﺮﺤﻧا ر ﻪﻠﺧاﺪﻣ زا ﻞﺒﻗ ﻦﯿﺗﺎﺘﺳﻮﻟ قﺎﻤﺳ+ﻦﯿﺗﺎﺘﺳﻮﻟ ﻊﻤﺟ ٢٩ ٢٩ ٥٨ ١٤١٫٨٢ ١٧١٫٥٢ ١٥٦٫٦٧ ٢٨٫٣٩ ٤٣٫٨٨ ٣٩٫٥٧ ﻪﻠﺧاﺪﻣ زا ﺪﻌﺑ ﻦﯿﺗﺎﺘﺳﻮﻟ قﺎﻤﺳ+ﻦﯿﺗﺎﺘﺳﻮﻟ ﻊﻤﺟ ٢٩ ٢٩ ٥٨ ١١٥٫٧٠ ١٤١٫٤٥ ١٢٨٫٥٧ ٣٤٫١٣ ٣٤٫٦٩ ٣٦٫٤٩
ﺢﻄﺳ ﺶﻫﺎﮐ ﻂﺳﻮﺘﻣ
LDLنارﺎـﻤﯿﺑ رد لوﺮﺘﺴﻠﮐ
ﻦﯿﺗﺎﺘﺳﻮﻟ ﺎﺑ هﺪﺷ نﺎﻣرد
12
/
26
ﺑ
نآ لﺎﺣ دﻮ
هوﺮﮔ رد ﻪﮐ
ﺑ ﻦﯿﺗﺎﺘﺳﻮﻟ ﺎﺑ نﺎﻣرد ﺖﺤﺗ
ﻪ
قﺎﻤـﺳ هوﻼـﻋ
07
/
30
دﻮـﺑ
.
هرﺎﻤﺷ لوﺪﺟ)
2(
هرﺎﻤﺷ لوﺪﺟ 2 . ﺢﻄﺳ ﺶﻫﺎﮐ ﻂﺳﻮﺘﻣ ﻪﺴﯾﺎﻘﻣ LDL ﺑ ﻦﯿﺗﺎﺘﺳﻮﻟ ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد ﻦﯿﺗﺎﺘﺳﻮﻟ ﺎﺑ نﺎﻣرد ﺖﺤﺗ داﺮﻓا رد ﻪ قﺎﻤﺳ هوﻼﻋ هوﺮﮔ داﺪﻌﺗ ﻦﯿﮕﻧﺎﯿﻣ رﺎﯿﻌﻣ فاﺮﺤﻧا t P-value ﻦﯿﺗﺎﺘﺳﻮﻟ ٢٩ ٢٦٫١٢ ٢٩.٦٧ ٠٫٦ ٠٫٥٤ قﺎﻤﺳ+ﻦﯿﺗﺎﺘﺳﻮﻟ ٢٩ ٣٠٫٠٧ ١٨٫٥٧ ٠٫٦ ٠٫٥٤
ﺶﻫﺎـﮐ ﺪـﺻرد ﻪـﺑ طﻮـﺑﺮﻣ يرﺎـﻣآ يﺎﻫ ﺺﺧﺎﺷ
ﺢﻄﺳ
LDLهرﺎﻤـﺷ لوﺪـﺟ رد هوﺮـﮔ ود ﺮﻫ رد مﺮﺳ
3
مﺎـﺠﻧا ﺎـﺑ ﻪﮐ ﺖﺳا هﺪﺷ هداد نﺎﺸﻧ
T testو
P<٠٫٨٣.دﻮﺒﻧ راد ﯽﻨﻌﻣ يرﺎﻣآ ﺮﻈﻧ زا فﻼﺘﺧا
هرﺎﻤﺷ لوﺪﺟ 3 . ﻪﺑ طﻮﺑﺮﻣ يرﺎﻣآ يﺎﻫ ﺺﺧﺎﺷ ﺢﻄﺳ ﺶﻫﺎﮐ ﺪﺻرد LDL ﻦﯿﺗﺎﺘﺳﻮﻟ ﺎﺑ نﺎﻣرد ﺖﺤﺗ داﺮﻓا رد ﺑ ﻦﯿﺗﺎﺘﺳﻮﻟ ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد ﻪ قﺎﻤﺳ هوﻼﻋ هوﺮﮔ داﺪﻌﺗ ﻦﯿﮕﻧﺎﯿﻣ ﺶﻫﺎﮐ ﺪﺻرد رﺎﯿﻌﻣ فاﺮﺤﻧا t P-value ﻦﯿﺗﺎﺘﺳﻮﻟ ٢٩ ١٨٪ ٠٫٢٣ ٠٫٢٢ ٠٫٨٣ قﺎﻤﺳ+ﻦﯿﺗﺎﺘﺳﻮﻟ ٢٩ ١٧٪ ٠٫٠٨ ٠٫٢٢ ٠٫٨٣
53
ﭘ مﻮﻠﻋ هﺎﮕﺸﻧاد ﯽﻤﻠﻋ ﻪﻠﺠﻣ مﻼﯾا ﯽﮑﺷﺰ هرود ﻢﻫﺪﻔﻫ هرﺎﻤﺷ ، مﻮﺳ ، ﺰﯿﯾﺎﭘ 88
يﺮﯿﮔ ﻪﺠﯿﺘﻧ و ﺚﺤﺑ
اد ﺰﯿﻟﺎـﻧآ ،ﺮـﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ رد
ﻪـﮐ داد نﺎـﺸﻧ ﺎـﻫ هد
ﺢﻄﺳ ﻦﯿﮕﻧﺎﯿﻣ
LDLﻪﻠﺧاﺪﻣ زا ﻞﺒﻗ درﻮﻣ هوﺮﮔ رد
171
ﺪﻫﺎــﺷ هوﺮــﮔ رد و
141
ﺮﺗﻻﺎــﺑ ﺢﻄــﺳ ﺮﮕﻧﺎــﯿﺑ ﻪــﮐ دﻮــﺑ
.ﺪـﺷﺎﺑ ﯽﻣ ﺪﻫﺎﺷ هوﺮﮔ ﻪﺑ ﺖﺒﺴﻧ درﻮﻣ هوﺮﮔ رد لوﺮﺘﺴﻠﮐ
رد و هوﺮـﮔ ود ﻦﯿـﺑ تاﺮـﯿﯿﻐﺗ نﺎـﻣﺰﻤﻫ ﻪﺴﯾﺎﻘﻣ ﻦﯾاﺮﺑﺎﻨﺑ
ﺖـﻠﻋ ﻦﯿﻤﻫ ﻪﺑ ،ﺪﯿﺳر ﯽﻤﻧ ﺮﻈﻧ ﻪﺑ ﻦﮑﻤﻣ ﺎﻫ هوﺮﮔ ﻞﺧاد
ﺳﻮﺘﻣ
ﺢﻄﺳ ﺶﻫﺎﮐ ﻂ
LDLﺢﻄـﺳ ﺶﻫﺎـﮐ ﺪـﺻ رد و
LDLﻦﯿﺗﺎﺘـﺳﻮﻟ و ﻦﯿﺗﺎﺘﺳﻮﻟ هﺪﻨﻨﮐ ﺖﻓﺎﯾرد هوﺮﮔ ود ﻦﯿﺑ
ﺑ
ﻪ
و ﯽـﺳرﺮﺑ درﻮﻣ ﯽﺋﺎﻬﻨﺗ ﻪﺑ قﺎﻤﺳ هوﻼﻋ
آ
راﺮـﻗ نﻮـﻣز
ﺶﻫﺎـﮐ ﻦﯿﮕﻧﺎـﯿﻣ ﻪـﮐ داد نﺎﺸﻧ ﺞﯾﺎﺘﻧ .ﺖﻓﺮﮔ
LDLرد
ﺘﺸﯿﺑ ﺪﻨﭼ ﺮﻫ درﻮﻣ هوﺮﮔ
ﺖـﺳا ﺪﻫﺎﺷ هوﺮﮔ زا ﺮ
ﻦـﯾا ﺎـﻣا ،
ﺖـﺴﯿﻧ راد ﯽﻨﻌﻣ يرﺎﻣآ ﺮﻈﻧ زا فﻼﺘﺧا
د
ﺪـﺻرد ﻊـﻗاو ر
درﻮﻣ هوﺮﮔ رد ﺶﻫﺎﮐ
17
ﺪـﺻرد
ﺪﻫﺎـﺷ هوﺮـﮔ رد و
18
ﺪﺻرد
.دﻮﺑ
ﺮـﺛا ﺎـﯿﻧﺮﻔﯿﻟﺎﮐ هﺎﮕـﺸﻧاد رد هﺪـﺷ مﺎـﺠﻧا ﻪﻌﻟﺎﻄﻣ رد
لوﺮﺘﺴﻠﮐ ﺶﻫﺎﮐ رد ﻦﯿﺗﺎﺘﺳﻮﻟ ﯽﺸﺨﺑ
25
ﺪﺻرد
شراﺰﮔ
ﺖﺳا هﺪﺷ
،)
16
ساﺰـﮑﺗ ﯽﺋاﻮﻫ يوﺮﯿﻧ رد ﻪﻌﻟﺎﻄﻣ ﺞﯾﺎﺘﻧ (
ﺶﻫﺎﮐ ﮏﯾ ﺰﯿﻧ
37
يﺮـﻧوﺮﮐ ثداﻮـﺣ عﻮﯿﺷ رد يﺪﺻرد
ـﻣرد زا ﺲﭘ
يﺮـﯿﮕﯿﭘ و ﻦﯿﺗﺎﺘـﺳﻮﻟ ﺎـﺑ نﺎ
5
نﺎـﺸﻧ ﻪﻟﺎـﺳ
داد
،)
17
(.
ءﺰـﺟ ﻪـﮐ داد نﺎـﺸﻧ نادﺎـﻧﺎﮐ ﻪﻌﻟﺎﻄﻣ ﯽﻓﺮﻃ زا
هﺪﻨﻨﮐ رﺎﻬﻣ ﮏﯾ ناﻮﻨﻋ ﻪﺑ (بآ رد لﻮﻠﺤﻣ)قﺎﻤﺳ ﯽﻟﻮﻧﺎﺘﻣ
ﺪﯿـﺴﮐاﺮﭘﻮﺳ لﺎـﮑﯾدار هﺪﻨﻨﮐ ﻊﻤﺟ و زاﺪﯿﺴﮐا ﯽﺘﺑﺎﻗر ﺮﯿﻏ
ﺪﻨﮐ ﯽﻣ ﻞﻤﻋ
،)
12
ﺶـﻘﻧ ﺰـﯿﻧ ﻦﯿﻣا و يرﻮﺳ ﻪﻌﻟﺎﻄﻣ رد .(
ﮕﺸﯿﭘ رد قﺎﻤﺳ ﯽﻧاﺪﯿﺴﮐا ﯽﺘﻧا
مﻼﻋا زوﺮﻠﮑﺳاوﺮﺗا زا يﺮﯿ
ﺖﺳا هﺪﺷ
،)
13
ﯽﻠﺿﺎﻓ ﻪﻌﻟﺎﻄﻣ .(
سﺎـﺒﻋ ﺮـﺻﺎﻧ ﻪﻌﻟﺎﻄﻣ و
ﺮﺛا
تاﺮـﺛا ﺮﺑ ﺎﻣا ،داد نﺎﺸﻧ ار قﺎﻤﺳ ندﻮﺑ ﮏﯿﺘﭙﺳ ﯽﺘﻧآ
ﺖﺳا هﺪﺸﻧ هرﺎﺷا نآ يﺪﯿﭙﯿﻟ ﯽﺘﻧآ
.)
18
،
20
(
ﺶﻨـﮐاو ﺮﺑ قﺎﻤﺳ ﯽﮔﺪﻨﻨﮐ رﺎﻬﻣ ﺮﺛا ﺦﯿﺷ ﻪﻌﻟﺎﻄﻣ
تاﺮـﺛا ﯽـﻟو ،ﺖـﺳا هدﻮﻤﻧ تﺎﺒﺛا ار ﻦﯿﻣﻮﺒﻟآ نﺪﺷ ﻪﮑﯿﻠﮔ
ﯽﺘﻧآ
).ﺖﺳا هﺪﯾدﺮﮕﻧ ﯽﺳرﺮﺑ نآ يﺪﯿﭙﯿﻟ
19
(
ﺗ ﺎﺑ
ــــ
يور ﺮـﺑ يدﺎـﯾز تﺎـﻌﻟﺎﻄﻣ ﻪـﮑﻨﯾا ﻪـﺑ ﻪﺟﻮ
ﺸﺨﺑﺮﺛا و قﺎﻤﺳ
ــــ
لوﺮﺘـﺴﻠﮐ ﺢﻄـﺳ ﺶﻫﺎـﮐ رد نآ ﯽ
ﻃ زا و ،ﺖﺳا هﺪﺸﻧ
ــــ
يور ﺮـﺑ ﺰـﯿﻧ ﺮـﺿﺎﺣ ﻪﻌﻟﺎﻄﻣ ﯽﻓﺮ
ﻤﯿﺑ زا ﯽﮐﺪﻧا داﺪﻌﺗ
ـــ
ﺠﻧا نارﺎ
ــــ
ﻬﻨﺸﯿﭘ ،ﺪـﺷ مﺎ
ـــــ
دﺎ
ﺗ هدﺮﺘﺴﮔ تﺎﻌﻟﺎﻄﻣ ددﺮﮔ ﯽﻣ
ــــ
ـﻤﯿﺑ داﺪـﻌﺗ ﺎـﺑ يﺮ
نارﺎ
ﺼﻣ تﺪﻣ لﻮﻃ و ﺮﺘﺸﯿﺑ
ــــ
ﻃ فﺮ
ــــ
قﺎﻤـﺳ ﺮـﺗ ﯽﻧﻻﻮ
.دﺮﯾﺬﭘ مﺎﺠﻧا
References
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١٠-Kosar M, Bozan B, Temelli F, Baser KHC. Antioxidant activity and phenolic composition of sumac (Rhus coriaria L) extracts. Food Chem ٢٠٠٦; ١٠٣: ٩٥٢-٩. ١١-Perchellet JP, Gali HU, Perchellet EM,
Klish DS, Armbrust
AD.Antitumor-promoting activities of tannic acid, ellagic acid, and several gallic acid derivatives in mouse skin. Basic Life Sci ١٩٩٢;٥٩: ٧٨٣-٨٠١.
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ﺶﻫﺎﮐ رد قﺎﻤﺳ ﺮﺛا ﯽﺳرﺮﺑ LDL ﻦﯿﺗﺎﺘﺳﻮﻟ ﺎﺑ ﻪﺴﯾﺎﻘﻣ رد لوﺮﺘﺴﻠﮐ - نارﺎﮑﻤﻫ و ﯽﻧادﺮﻣ زﺎﻨﻬﻣ
A Study on The Effects of Rhus Coriaria (Somac) on LDL
Cholesterol Level Compared with Lovastatin
Raufi A1, Mardani M2*, Sabagh M3, Delfan B4, Tarahi M.J5
(Received: 5 Des, 2008 Accepted: 8Aug, 2009)
Abstract
Introduction:
Ischemic heart disease, more than any other disease, leads to mortality and morbidity and high economical costs in developed countries. A cardiovascular disease, especially atherosclerosis, is predicted to become the most important disease in 2020. A disorder which reduces the quality of life due to early death and deterioration. Today, lipid metabolism and lipoprotein disorders have come to be themost important risk factors of
atherosclerosis. So,management and
treatment of dyslipidemia, is considered an effective preventive method. Considering the high level of atherosclerosis rate in khorramabad (western-center Iran) as well as several reports on anti oxidative effects of Rhus coriaria , this study was planned to compare the effects of lovastatin and Rhus coriaria in decreasing LDL cholesterol level.
Materials & Methods:
In this study, 86 patients with elevated LDL cholesterol levels, having the indications to enter the study, were selected and divided into two groups of 43 people. Group 1(control group) underwent treatment with lovastatin,and group 2(case group) took
lovastatin+Rhus coriria as their cure. After
3 months, LDL cholesterol levels were measured in both the groups.
Findings:
58 patients of all the 86 patientscompleted the tests. The mean LDL levels in the control and case groups before intervention were 141,82 and 171,52 respectively. After intervention, they were 115,7 in the control and 141,45 in the case group. Due to higher level of LDL in the case group vs. the control one before the intervention, the mean level of LDL decreased and its percentage was measured. The decrease of LDL level in the case group was 17%, while it was 18% in the control cases. Nevertheless, thw mean decrease in case patients was 30,07, while it was 26,12 in the control ones, a difference which was not significant statically.
Discussion & Conclusion:
Due to insignificant decrease of LDL level in both the groups of patients, using Rhus coriaria (Somac) is not recommended as an effective factor in treating patients suffering from high levels of LDL cholesterol.Key words:
ischemic heart disease, atherosclerosis, lipoprotein, dyslipidemia, Rhus coriaria.
1.Dept of Cardiology, Faculty of Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran
2.Dept of Nutrition, Faculty of Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran(corresponding author) 3.Stud of Medicine, Faculty of Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran
4.Dept of Pharmacology, Faculty of Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran
5.Dept of Statistics, Health College, Faculty of Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran
Scientific Journal of Ilam University of Medical Sciences
