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Vitamin D receptor signaling improves Hutchinson-Gilford progeria syndrome cellular phenotypes

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Figure

Figure 1: VDR deficiency in cells with disrupted nuclear lamina. A. Human NF lentivirally transduced with shRNA targeting lamin A/C (shLmna) or scrambled (shscr), and processed for immunoblotting (2 independent transductions)
Figure 2: Phenotypes of HGPS cells are rescued by vitamin D. A.fluorescence units) in NFs and in HGPS cells subjected to prolonged treatment with vehicle or 1,25D
Figure 3: Vitamin D rescues nuclear abnormalities and delays senescence in HGPS cells
Figure 4: Regulation of LMNA gene expression by vitamin D/VDR. A. RNAseq analysis performed in NF after a 24-h treatment with 1,25D (10-7M) or vehicle (FBS) as control
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