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MLN-8237: A dual inhibitor of aurora A and B in soft tissue sarcomas

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Figure

Figure 1: Aurora Kinase Inhibitor MLN8237 induces growth suppression. (A) (i) Chemical structure of MLN-8237
Figure 3B and 3B (i) explains the FACScan analysis with
Figure 3: Differential inhibition of MLN-8237 in cell lines other than sarcoma. (A) Uveal melanoma cells; OCM1, OCM1A, OCM3,  Mel270 and Mel290 were exposed to 0.1 and 1 µM of MLN-8237 for 48 hours and harvested for (i) western blot analysis probing for cl
Figure 4: MLN-8237 induces differential effect in a dose dependent manner. HCT116 cells transfected with GFP-histone 2B for 24 h were treated with 0.1 (A) or 1 µM (B) MLN-8237 and live cell imaging was done after 18 h of exposure as described in Materials
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