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Original Article Thioredoxin-1 inhibitor PX-12 induces human acute myeloid leukemia cell apoptosis and enhances the sensitivity of cells to arsenic trioxide

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Figure

Figure 1. The Trx-1 inhibitor PX-12 inhibits growth of human AML cells. AML cell lines (NB4, HL-60 and U937) and primary AML cells were treated with various concentrations of PX-12
Figure 2. PX-12 induces apoptosis in AML cells. AML cells were treated for 48 h with various concentrations of PX-12
Figure 3. Effects of PX-12 on level of caspase-3 expression in AML cells. A. Representatives were shown in AML cells treated by 5 μM PX-12 for 48 h
Figure 4. Comparison of cell growth inhibition and Trx-1 expression induc-
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