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Original Article Drug-drug interaction potential of 1,5-dicaffeylquinic acid, a new herbal drug for the treatment of hepatitis B and human immunodeficiency virus infection, based on the inhibition of cytochrome P450s in human and rat liver microsomes

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Figure

Figure 1. The chemical structure of 1,5-dicaffeylquinic acid.
Table 1. Incubation conditions and analytical parameters for the individual metabolites and internal standards
Figure 2. In vitro inhibitory effects of 1,5-DCQA (100, 30, 10, 3.0, 1.0, 0.3, 0.1, and 0.03 μM) on rat CYP1a2/2c7/2c11/2c79/2d4/3a2 using the enzyme-substrate cocktail method
Figure 3. In vitro inhibitory effects of 1,5-DCQA (100, 30, 10, 3.0, 1.0, 0.3, 0.1, and 0.03 μM) on human CYP1A2/2C8/2C9/2C19/2D6/CYP3A4 using the enzyme-substrate cocktail method

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