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Immunological Intolerance and Tolerance by Antigenic Co Stimulation

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Figure

Figure 1. Effector and memory lymphocytes lineages are generated in both tolerant and intolerant status
Figure 2. (a) Classical immunogenic model: After antigen inoculation in a single site (1), the presentation occurs in secondary lymphoid organs such as spleen and lymph nodes (2) where effector and memory cells proliferate to an intense inflammatory respon
Figure 3. Models of intolerant and tolerant profiles from homogenous and heterogenous APC profile
Figure 4. Homogenous profile from antigen presenting cells leads to convergence for an intolerant profile (unstable imune status), while signals from multiple or tolerant sites cause tolerance (transient and steady status)

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