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Functional and molecular evidence for heteromeric association of P2Y1 receptor with P2Y2 and P2Y4 receptors in mouse granulocytes

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Figure

Fig. 1 Characterization of P2 responses in mice granulocytes. Granulocytes were loaded with the Casame sensitivity to G2+ indicator fura-2
Fig. 2 Presence of P2Y receptors in bone marrow granulocytes.a Granulocytes expressed mRNA for P2Y1, P2Y2, P2Y4 and P2Y12receptors
Fig. 3 Cross-desensitization among ATP, ADP and UTP in mice granulocytes. Granulocytes were loaded with the Ca2+ indicator fura-2.a–d Addition of ATP fully inhibited responses to ADP and UTP and vice-versa
Fig. 4 Heteromeric association among P2Y receptors.asecondary antibody: P2Y a Immunoprecipitation (IP) of cell lysates visualized by western blot (WB) analyses
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