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A small peptide antagonist of the Fas receptor inhibits neuroinflammation and prevents axon degeneration and retinal ganglion cell death in an inducible mouse model of glaucoma

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Figure

Table 1 RNA primers used for qPCR
Fig. 1 ONL1204 rescues A20 B lymphoma cells from FasL-mediated apoptosis. The ability of ONL1204 to inhibit FasL-mediated apoptosis ofmurine A20 B lymphoma cells was evaluated in vitro
Fig. 2 Fas signaling pathway is required for death of RGCs and loss of axons in microbead-induced model of glaucoma.were taken by rebound tonometry in WT and Fas-deficient Fas a IOP measurementslpr mice injected with microbeads or saline
Fig. 3 Pre-elevated IOP treatment with ONL1204 protects RGCs and prevents axon degeneration in microbead-induced model of glaucoma
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