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Lipid metabolism reprogramming and its potential targets in cancer

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Figure

Fig. 1 Regulation of lipid metabolism in cancer cells. In cancer cells, glucose uptake and glycolysis are markedly up-regulated by RTKs via the synthetase 2, PI3K/Akt/mTOR signaling pathway, generating large amounts of pyruvate
Fig. 2 SCAP N-glycosylation is essential for SREBP trafficking and activation. SREBP activation is repressed by the ER-resident protein Insig, which binds to SCAP to prevent SREBP translocation and nuclear activation
Table 1 Representative targets within the lipid metabolism pathway for anti-cancer drug development

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