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Transforming growth factor beta (TGF-β) is activated by the CtBP2-p300-AP1 transcriptional complex in chronic renal failure

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Academic year: 2020

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Figure 1. The serum concentration of TGF-β was elevated and TGF-β signaling was activated in CRF patients (A) Serum concentrations of TGF-βwere associated with the CRF stage
Figure 2. Knockdown of AP-1 subunits caused the downregulation of TGFB1. (A) The promoter of TGFB1 contained one AP-1 and four NF-κB binding sites
Figure 3. CtBP2 formed transcriptional complexes with p300 and c-Jun or c-FOS. (A) In vivopCDNA3-6pCDNA3-6 pull-down of the Flag-c-Jun- and c-FOS-associated complexes
Figure 4. The CtBP2-p300-AP1 transcriptional complexes were upregulated in CRF patients
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