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DNA-PKcs Negatively Regulates Cyclin B1 Protein Stability through Facilitating Its Ubiquitination Mediated by Cdh1-APC/C Pathway

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Figure

Fig 1. DNA-PKcs deficiency increases the stability of Cyclin B1 protein. ((DPK-siRNA)
Fig 2. Inactivation of DNA-PKcs attenuates the ubiquitination of Cyclin B1. (A) Depressing DNA-PKcs by specific DPK-siRNA attenuates the ubiquitination of cyclin B1 protein
Fig 3. The effects of DNA-PKcs deficiency on expression of APC/C co-activators Cdc20 and Cdh1
Fig 4. Immunoprecipiation demonstrates the interaction of DNA-PKcs with APC/C co-activator and Cyclin B1
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