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Assessment of Interspecies Differences in Drug-Induced QTc Interval Prolongation in Cynomolgus Monkeys, Dogs and Humans.

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Figure

Table I Pre-clinical and clinical experimental protocol design and population characteristics for moxifloxacin (A) and NCE05 (B)
Table III Moxifloxacin pharmacokinetic population parameter estimates
Figure 5 summarises the goodness-of-fit plots and the curves describing the relation between the drug  concentra-tion and the probability of a QT interval prolongaconcentra-tion
Fig. 3 Model performance and predicted QT profiles after administration of placebo and different doses of moxifloxacin to dogs (left panels), cynomolgus monkeys (mid panels) and humans (right panels)

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