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Polarization of macrophages in the tumor microenvironment is influenced by EGFR signaling within colon cancer cells

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Figure 1: Cetuximab modulates macrophage polarization in an AOM/DSS mouse model. A. Establishment of the AOM/DSS mouse model
Figure 2: Inhibition of the EGFR signaling pathway in colon cancer cells prevents conditioned medium-induced M2-like macrophage polarization
Figure 3: EGFR knockout in colon cancer cells inhibits macrophage-induced promotion of xenograft tumor growth
Figure 4: Colon cancer-derived IGF-1 promotes M2-like macrophage polarization. A. IGF-1 concentrations were determined by ELISA in SW620 and SW620 EGFR cell culture media
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